https://wikimd.org/index.php?action=history&feed=atom&title=Enarodustat Enarodustat - Revision history 2026-04-25T23:43:44Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.org/index.php?title=Enarodustat&diff=6493250&oldid=prev Prab at 20:28, 16 March 2025 2025-03-16T20:28:39Z <p></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 20:28, 16 March 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l74">Line 74:</td> <td colspan="2" class="diff-lineno">Line 74:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; 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font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">{{No image}}</del></div></td><td colspan="2" class="diff-side-added"></td></tr> </table> Prab https://wikimd.org/index.php?title=Enarodustat&diff=6231399&oldid=prev Prab: CSV import 2025-02-10T16:38:52Z <p>CSV import</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 16:38, 10 February 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l74">Line 74:</td> <td colspan="2" class="diff-lineno">Line 74:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; 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font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">{{No image}}</ins></div></td></tr> </table> Prab https://wikimd.org/index.php?title=Enarodustat&diff=5903144&oldid=prev Prab: CSV import 2024-06-13T00:01:53Z <p>CSV import</p> <p><b>New page</b></p><div>{{Short description|Hypoxia-inducible factor prolyl hydroxylase inhibitor}}<br /> {{Drugbox<br /> | Verifiedfields = changed<br /> | Watchedfields = changed<br /> | verifiedrevid = 477002123<br /> | IUPAC_name = (2S)-2-[[4-[(4-chlorophenyl)methyl]phenyl]methyl]-1-[(2S)-2-hydroxy-2-phenylethyl]-2,3-dihydro-1H-imidazo[4,5-b]pyridin-2-yl]ethanone<br /> | image = Enarodustat.svg<br /> | width = 250<br /> | tradename = <br /> | Drugs.com = <br /> | MedlinePlus = <br /> | pregnancy_AU = <br /> | pregnancy_category = <br /> | legal_AU = <br /> | legal_CA = <br /> | legal_UK = <br /> | legal_US = <br /> | legal_status = <br /> | routes_of_administration = <br /> | bioavailability = <br /> | protein_bound = <br /> | metabolism = <br /> | elimination_half-life = <br /> | excretion = <br /> | CAS_number = 1262132-82-0<br /> | ATC_prefix = <br /> | ATC_suffix = <br /> | PubChem = 49846519<br /> | DrugBank = <br /> | ChemSpiderID = 28535835<br /> | UNII = <br /> | KEGG = <br /> | ChEBI = <br /> | ChEMBL = 2103870<br /> | synonyms = JTZ-951<br /> | C=24<br /> | H=22<br /> | Cl=1<br /> | N=3<br /> | O=2<br /> | smiles = C1=CC=C(C=C1)C(C2=CC=C(C=C2)CC3=NC4=C(N3CC(C5=CC=CC=C5)O)N=CC=C4)=O<br /> | StdInChI = 1S/C24H22ClN3O2/c25-18-10-8-17(9-11-18)14-19-6-4-16(5-7-19)13-22-27-23-20(12-15-26-24(23)28-22)21(29)24(30)31-24/h4-12,24,30H,13-15H2<br /> | StdInChIKey = <br /> }}<br /> <br /> &#039;&#039;&#039;Enarodustat&#039;&#039;&#039; is a [[hypoxia-inducible factor prolyl hydroxylase inhibitor]] (HIF-PHI) used in the treatment of [[anemia]] associated with [[chronic kidney disease]] (CKD). It works by stabilizing the [[hypoxia-inducible factor]] (HIF), which in turn stimulates the production of [[erythropoietin]] and enhances [[erythropoiesis]].<br /> <br /> == Mechanism of Action ==<br /> Enarodustat inhibits the activity of [[prolyl hydroxylase]], an enzyme responsible for the degradation of HIF under normal oxygen conditions. By inhibiting this enzyme, enarodustat allows HIF to accumulate and activate the transcription of genes involved in [[erythropoiesis]], iron metabolism, and oxygen transport.<br /> <br /> == Clinical Use ==<br /> Enarodustat is primarily indicated for the treatment of anemia in patients with chronic kidney disease. It offers an alternative to traditional [[erythropoiesis-stimulating agents]] (ESAs) and may provide benefits in terms of reducing the need for [[intravenous iron]] supplementation.<br /> <br /> == Pharmacokinetics ==<br /> The pharmacokinetic profile of enarodustat includes oral bioavailability, protein binding, metabolism, and elimination half-life. Detailed pharmacokinetic data are essential for understanding the dosing regimen and potential drug interactions.<br /> <br /> == Side Effects ==<br /> Common side effects of enarodustat may include [[hypertension]], [[nausea]], and [[diarrhea]]. Monitoring for adverse effects is crucial, especially in patients with underlying cardiovascular conditions.<br /> <br /> == Related Pages ==<br /> * [[Anemia]]<br /> * [[Chronic kidney disease]]<br /> * [[Erythropoiesis]]<br /> * [[Hypoxia-inducible factor]]<br /> * [[Prolyl hydroxylase]]<br /> <br /> == References ==<br /> {{Reflist}}<br /> <br /> [[Category:Drugs]]<br /> [[Category:Anemia]]<br /> [[Category:Chronic kidney disease]]<br /> [[Category:Hypoxia-inducible factor prolyl hydroxylase inhibitors]]<br /> <br /> {{hospital-stub}}</div> Prab