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	~~'''~~ERV3~~''' or '''Endogenous Retrovirus 3''' is a type of [[endogenous retrovirus]] that is found in the [[genome]] of humans and other primates. It is one of the many [[retrovirus~~\|~~retroviruses]] that have been incorporated into the genetic material of our ancestors and passed down through generations~~.		{{Infobox gene
			\| name = ERV3
			\| image = <!-- Image removed -->
			\| caption =
			\| symbol = ERV3
			\| alt_symbols =
			\| EntrezGene = 2087
			\| HGNCid = 3436
			\| OMIM = 142460
			\| RefSeq = NM_001007251
			\| UniProt = P61812
			\| chromosome = 7
			\| arm = q
			\| band = 11.23
			}}

	~~== Overview ==~~		'''ERV3''' (Endogenous Retrovirus Group 3) is a [[human endogenous retrovirus]] (HERV) that is part of the human genome. It is located on [[chromosome 7]] at the q11.23 region.

	~~[[File:ERV3_structure.png\|thumb\|right\|Structure of ERV3]]~~

	ERV3 is a ~~unique~~ endogenous retrovirus ~~as it~~ is ~~one~~ of the ~~few that is still capable of producing viral particles~~. It is located on [[chromosome 7]] ~~and is thought to play a role in placental development and function~~.

	== Function ==		== Function ==
			ERV3 is one of the many [[endogenous retroviruses]] that have integrated into the human genome over millions of years. These sequences are remnants of ancient viral infections that have become fixed in the germline DNA. While most HERVs are non-functional, some have been co-opted by the host for beneficial purposes.

	The ~~exact function~~ of ERV3 is ~~not fully understood~~, ~~but it is believed to play~~ a role in ~~the development and function of the~~ [[~~placenta~~]]. ~~Some studies have suggested that ERV3 may be involved in the regulation of~~ [[~~gene expression~~]] ~~in the placenta~~, ~~and~~ may ~~also play a role in protecting the fetus from other viral infections~~.		== Expression ==
			The expression of ERV3 is tissue-specific and has been detected in the [[placenta]], suggesting a potential role in [[placental development]]. The [[envelope protein]] of ERV3 has been studied for its possible immunosuppressive properties, which may contribute to maternal-fetal tolerance during pregnancy.
	~~== Clinical significance ==~~

	~~Alterations in the~~ expression of ERV3 ~~have~~ been ~~associated with several diseases, including~~ [[~~schizophrenia~~]], [[~~rheumatoid arthritis~~]], and [[~~cancer~~]]. ~~However,~~ the ~~exact role~~ of ~~ERV3 in~~ these ~~diseases is not yet fully understood~~ and ~~is the subject of ongoing research.~~		== Clinical Significance ==
			Altered expression of ERV3 has been observed in certain [[cancers]], including [[breast cancer]] and [[melanoma]]. Research is ongoing to determine the implications of these findings and whether ERV3 could serve as a [[biomarker]] for cancer diagnosis or prognosis.
	~~== Research ==~~

	~~Research into~~ ERV3 ~~and other endogenous retroviruses is~~ a ~~rapidly growing field, with potential implications~~ for ~~our understanding of human evolution, development, and disease~~.

	~~== See also ==~~

			== See Also ==
	* [[Endogenous retrovirus]]		* [[Endogenous retrovirus]]
	* [[Retrovirus]]
	* [[Human genome]]		* [[Human genome]]
	* [[~~Gene expression~~]]		* [[Placental development]]

	== References ==		== References ==
			{{Reflist}}

	~~<references~~ />		== External Links ==
			* [https://www.ncbi.nlm.nih.gov/gene/2087 ERV3 Gene - NCBI]
	~~{{medicine~~-~~stub}}~~		* [https://www.uniprot.org/uniprot/P61812 ERV3 Protein - UniProt]

	[[Category:~~Genetics~~]]		[[Category:Human genes]]
	[[Category:~~Virology~~]]		[[Category:Endogenous retroviruses]]
	[[Category:~~Medicine~~]]		[[Category:Chromosome 7]]

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'''ERV3''' or '''Endogenous Retrovirus 3''' is a type of [[endogenous retrovirus]] that is found in the [[genome]] of humans and other primates. It is one of the many [[retrovirus|retroviruses]] that have been incorporated into the genetic material of our ancestors and passed down through generations.

== Overview ==

[[File:ERV3_structure.png|thumb|right|Structure of ERV3]]

ERV3 is a unique endogenous retrovirus as it is one of the few that is still capable of producing viral particles. It is located on [[chromosome 7]] and is thought to play a role in placental development and function.

== Function ==

The exact function of ERV3 is not fully understood, but it is believed to play a role in the development and function of the [[placenta]]. Some studies have suggested that ERV3 may be involved in the regulation of [[gene expression]] in the placenta, and may also play a role in protecting the fetus from other viral infections.

== Clinical significance ==

Alterations in the expression of ERV3 have been associated with several diseases, including [[schizophrenia]], [[rheumatoid arthritis]], and [[cancer]]. However, the exact role of ERV3 in these diseases is not yet fully understood and is the subject of ongoing research.

== Research ==

Research into ERV3 and other endogenous retroviruses is a rapidly growing field, with potential implications for our understanding of human evolution, development, and disease.

== See also ==

* [[Endogenous retrovirus]]
* [[Retrovirus]]
* [[Human genome]]
* [[Gene expression]]

== References ==

<references />

{{medicine-stub}}

[[Category:Genetics]]
[[Category:Virology]]
[[Category:Medicine]]

ERV3 - Revision history

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