Prab at 20:28, 16 March 2025

2025-03-16T20:28:19Z

← Older revision		Revision as of 20:28, 16 March 2025
Line 34:		Line 34:
	{{neuroscience-stub}}		{{neuroscience-stub}}
	{{medicine-stub}}		{{medicine-stub}}
	~~{{No image}}~~
	~~{{No image}}~~
	<gallery>		<gallery>
	File:Dynorphin A.svg\|Dynorphin A		File:Dynorphin A.svg\|Dynorphin A
	</gallery>		</gallery>

Prab: CSV import

2025-03-03T05:06:14Z

CSV import

← Older revision		Revision as of 05:06, 3 March 2025
Line 36:		Line 36:
	{{No image}}		{{No image}}
	{{No image}}		{{No image}}
			<gallery>
			File:Dynorphin A.svg\|Dynorphin A
			</gallery>

Prab: CSV import

2025-02-10T15:56:54Z

CSV import

← Older revision		Revision as of 15:56, 10 February 2025
Line 34:		Line 34:
	{{neuroscience-stub}}		{{neuroscience-stub}}
	{{medicine-stub}}		{{medicine-stub}}
			{{No image}}
	{{No image}}		{{No image}}

Prab: CSV import

2025-02-10T15:50:36Z

CSV import

← Older revision		Revision as of 15:50, 10 February 2025
Line 34:		Line 34:
	{{neuroscience-stub}}		{{neuroscience-stub}}
	{{medicine-stub}}		{{medicine-stub}}
			{{No image}}

Prab: CSV import

2024-02-28T20:48:44Z

CSV import

New page

'''Dynorphin A''' is a [[neuropeptide]] that belongs to the [[dynorphin]] family. It is an endogenous [[opioid]] that is found in neurons in many different parts of the brain, including the [[hypothalamus]], [[hippocampus]], and [[spinal cord]]. Dynorphin A is known for its role in modulating pain and maintaining the body's response to stress.

== Structure and Function ==

Dynorphin A is a peptide that consists of 17 [[amino acids]]. It is derived from the precursor protein [[prodynorphin]], which is cleaved to produce dynorphin A, along with other dynorphins.

Dynorphin A functions by binding to and activating the [[kappa opioid receptor]] (KOR). This receptor is a type of [[G protein-coupled receptor]] that is found in the nervous system. When dynorphin A binds to KOR, it triggers a series of events inside the cell that ultimately lead to the inhibition of [[adenylate cyclase]], a decrease in the production of [[cAMP]], and a reduction in neuronal excitability.

== Role in Pain and Stress ==

Dynorphin A is best known for its role in modulating pain. It is released in response to painful stimuli and acts to inhibit the transmission of pain signals in the spinal cord. This makes dynorphin A a key player in the body's natural pain relief system.

In addition to its role in pain, dynorphin A is also involved in the body's response to stress. It is released in response to stressors and acts to inhibit the release of [[corticotropin-releasing hormone]] (CRH) from the hypothalamus. This helps to dampen the body's stress response and prevent overactivation of the [[hypothalamic-pituitary-adrenal axis]] (HPA axis).

== Clinical Significance ==

Due to its role in pain and stress, dynorphin A is a potential target for the development of new drugs for the treatment of chronic pain and stress-related disorders. However, the development of drugs that target the kappa opioid system has been challenging due to the complex pharmacology of this system and the potential for side effects.

== See Also ==

* [[Dynorphin B]]
* [[Big dynorphin]]
* [[Kappa opioid receptor]]
* [[Prodynorphin]]

== References ==

{{reflist}}

[[Category:Neuropeptides]]
[[Category:Opioids]]
[[Category:Stress]]
[[Category:Pain]]
{{neuroscience-stub}}
{{medicine-stub}}

Dynorphin A - Revision history

Prab at 20:28, 16 March 2025

Prab: CSV import

Prab: CSV import

Prab: CSV import

Prab: CSV import