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Dosulepin - Revision history
2026-04-23T07:29:59Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 01:00, 18 February 2025</td>
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2024-02-22T01:08:34Z
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<p><b>New page</b></p><div>'''Dosulepin''', also known as '''dothiepin''', is a [[tricyclic antidepressant]] (TCA) that is used in the treatment of [[depression]]. It is sold under several brand names, including Prothiaden, Dothep, Thaden and Dopress.<br />
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==Pharmacology==<br />
Dosulepin is a potent inhibitor of [[serotonin]] and [[norepinephrine]] reuptake, leading to an increase in the concentration of these neurotransmitters in the synaptic cleft and therefore an enhancement of neurotransmission. It is also a potent blocker of [[histamine H1 receptors]] and [[muscarinic acetylcholine receptors]], which accounts for its sedative and anticholinergic (drying) effects, respectively.<br />
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==Clinical use==<br />
Dosulepin is used primarily in the treatment of depression, but is also used in the management of [[neuropathic pain]] and [[fibromyalgia]]. It has a similar efficacy to other TCAs and is generally well-tolerated.<br />
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==Side effects==<br />
Common side effects of dosulepin include dry mouth, blurred vision, constipation, urinary retention, sweating, weight gain, and [[orthostatic hypotension]]. More serious side effects may include [[cardiac arrhythmias]], [[seizures]], and increased risk of [[suicide]].<br />
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==Contraindications==<br />
Dosulepin is contraindicated in individuals with known hypersensitivity to the drug, recent [[myocardial infarction]], arrhythmias, and severe liver disease.<br />
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==Interactions==<br />
Dosulepin may interact with other medications, including other antidepressants, antipsychotics, antihistamines, and anticholinergics, leading to an increased risk of side effects.<br />
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==See also==<br />
* [[Tricyclic antidepressant]]<br />
* [[Serotonin]]<br />
* [[Norepinephrine]]<br />
* [[Histamine H1 receptor]]<br />
* [[Muscarinic acetylcholine receptor]]<br />
* [[Neuropathic pain]]<br />
* [[Fibromyalgia]]<br />
* [[Orthostatic hypotension]]<br />
* [[Cardiac arrhythmia]]<br />
* [[Seizure]]<br />
* [[Suicide]]<br />
* [[Myocardial infarction]]<br />
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[[Category:Antidepressants]]<br />
[[Category:Tricyclic antidepressants]]<br />
[[Category:Pharmacology]]<br />
[[Category:Medicine]]<br />
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