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	[[Category:Beta-lactam antibiotics]]		[[Category:Beta-lactam antibiotics]]
	[[Category:Antibiotics]]		[[Category:Antibiotics]]
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			File:Doripenem.svg\|Doripenem
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	~~'''~~Doripenem~~''' is a [[carbapenem]] [[antibiotic]] that is marketed under the trade name '''Doribax''' by [[Janssen Pharmaceutica]]~~. ~~It is primarily used in the treatment of [[bacterial infections]] that are severe or life~~-~~threatening.~~		{{Short description\|An overview of the antibiotic doripenem}}
			{{Drugbox
			\| verifiedfields = changed
			\| verifiedrevid = 477002123
			\| image = Doripenem.svg
			\| image2 = <!-- Another image if available -->
			}}

	~~== History ==~~		'''Doripenem''' is a [[carbapenem]] [[antibiotic]] used in the treatment of severe [[bacterial infections]]. It is a member of the [[beta-lactam]] class of antibiotics, which work by inhibiting [[cell wall]] synthesis in bacteria, leading to cell death. Doripenem is particularly effective against a broad range of [[Gram-negative bacteria]], including [[Pseudomonas aeruginosa]].

	Doripenem ~~was approved~~ by ~~the~~ [[~~Food and Drug Administration\|FDA~~]] ~~in 2007~~. ~~It was developed by~~ [[~~Shionogi Inc.~~]], ~~a Japanese pharmaceutical company,~~ and ~~later licensed to Janssen Pharmaceutica, a division of [[Johnson & Johnson]]~~.		==Mechanism of Action==
			Doripenem exerts its antibacterial effects by binding to [[penicillin-binding proteins]] (PBPs) located inside the bacterial cell wall. This binding inhibits the final transpeptidation step of [[peptidoglycan]] synthesis, which is essential for bacterial cell wall integrity. The disruption of cell wall synthesis ultimately leads to bacterial cell lysis and death.

	== ~~Medical uses~~ ==		==Clinical Uses==
			Doripenem is primarily used to treat complicated [[intra-abdominal infections]] and [[urinary tract infections]], including [[pyelonephritis]]. It is also used in the treatment of [[nosocomial pneumonia]], including [[ventilator-associated pneumonia]]. Due to its broad-spectrum activity, doripenem is often reserved for severe infections caused by multi-drug resistant organisms.

	Doripenem is ~~used to treat~~ a ~~variety~~ of ~~bacterial infections~~, ~~including [[pneumonia]], [[urinary tract infection\|~~urinary tract infections]], and ~~[[intra-abdominal infection\|intra-~~abdominal ~~infections]]. It is also used in the treatment of [[nosocomial infections]], which are infections that are acquired in hospitals or other healthcare facilities~~.		==Pharmacokinetics==
			Doripenem is administered intravenously and has a half-life of approximately one hour. It is primarily excreted unchanged in the urine, making it suitable for treating urinary tract infections. The drug's pharmacokinetic profile allows for effective penetration into various body tissues, including the lungs and abdominal cavity.

	== ~~Mechanism of action~~ ==		==Side Effects==
			Common side effects of doripenem include [[nausea]], [[diarrhea]], [[headache]], and [[rash]]. Serious side effects may include [[allergic reactions]], [[seizures]], and [[Clostridium difficile infection]]. As with other beta-lactam antibiotics, caution is advised in patients with a history of [[penicillin allergy]].

	~~Doripenem works by inhibiting~~ the ~~synthesis~~ of the ~~bacterial cell wall~~, ~~leading to cell death~~. ~~It is a broad~~-~~spectrum antibiotic, meaning it~~ is ~~effective against~~ a ~~wide range of bacteria~~.		==Resistance==
			Bacterial resistance to doripenem can occur through various mechanisms, including the production of [[beta-lactamase]] enzymes that degrade the antibiotic, alterations in PBPs, and changes in [[porin]] channels that reduce drug uptake. The emergence of carbapenem-resistant [[Enterobacteriaceae]] (CRE) is a significant concern in clinical settings.

	== ~~Side effects~~ ==		==Related pages==

	~~Common side effects of doripenem include [[nausea]], [[diarrhea]], [[headache]], and [[rash]]. In rare cases, it can cause serious side effects such as [[anaphylaxis]], a severe allergic reaction.~~

	~~== Resistance ==~~

	~~Like other antibiotics, the effectiveness of doripenem can be reduced by [[antibiotic resistance]]. This occurs when bacteria evolve mechanisms to survive exposure to the antibiotic.~~

	~~== See also ==~~

	* [[Carbapenem]]
	* [[Antibiotic resistance]]		* [[Antibiotic resistance]]
	* [[~~Nosocomial infection~~]]		* [[Beta-lactam antibiotics]]
			* [[Carbapenem-resistant Enterobacteriaceae]]
			* [[Pseudomonas aeruginosa]]

			[[Category:Carbapenem antibiotics]]
			[[Category:Beta-lactam antibiotics]]
	[[Category:Antibiotics]]		[[Category:Antibiotics]]
	~~[[Category:Carbapenem antibiotics]]~~
	~~{{medicine-stub}}~~

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New page

'''Doripenem''' is a [[carbapenem]] [[antibiotic]] that is marketed under the trade name '''Doribax''' by [[Janssen Pharmaceutica]]. It is primarily used in the treatment of [[bacterial infections]] that are severe or life-threatening.

== History ==

Doripenem was approved by the [[Food and Drug Administration|FDA]] in 2007. It was developed by [[Shionogi Inc.]], a Japanese pharmaceutical company, and later licensed to Janssen Pharmaceutica, a division of [[Johnson & Johnson]].

== Medical uses ==

Doripenem is used to treat a variety of bacterial infections, including [[pneumonia]], [[urinary tract infection|urinary tract infections]], and [[intra-abdominal infection|intra-abdominal infections]]. It is also used in the treatment of [[nosocomial infections]], which are infections that are acquired in hospitals or other healthcare facilities.

== Mechanism of action ==

Doripenem works by inhibiting the synthesis of the bacterial cell wall, leading to cell death. It is a broad-spectrum antibiotic, meaning it is effective against a wide range of bacteria.

== Side effects ==

Common side effects of doripenem include [[nausea]], [[diarrhea]], [[headache]], and [[rash]]. In rare cases, it can cause serious side effects such as [[anaphylaxis]], a severe allergic reaction.

== Resistance ==

Like other antibiotics, the effectiveness of doripenem can be reduced by [[antibiotic resistance]]. This occurs when bacteria evolve mechanisms to survive exposure to the antibiotic.

== See also ==

* [[Carbapenem]]
* [[Antibiotic resistance]]
* [[Nosocomial infection]]

[[Category:Antibiotics]]
[[Category:Carbapenem antibiotics]]
{{medicine-stub}}

Doripenem - Revision history

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