https://wikimd.org/index.php?action=history&feed=atom&title=DocusateDocusate - Revision history2026-05-12T10:59:52ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.org/index.php?title=Docusate&diff=5498636&oldid=prevKondreddy Naveen at 23:54, 4 April 20242024-04-04T23:54:10Z<p></p>
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Docusate is an orally available, over-the-counter laxative and stool softener used to treat or prevent constipation. <br />
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[[File:Docusate Structure.svg|thumb|Docusate Structure]]<br />
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Docusate has not been linked to serum enzyme elevations during therapy or to clinically apparent liver injury with jaundice.<br />
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Docusate (dok’ ue sate) is a stool softener and surfactant previously known as dioctyl sodium [or calcium] sulfosuccinate (DSS). <br />
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Docusate is commonly used to treat or prevent constipation and to promote bowel regularity in hospitalized, bed-bound or immobilized persons. Docusate salts are thought to act as detergents, reducing surface tension of liquids and fatty substances in the intestine, thereby softening stool consistency. The efficacy of docusate in treatment and prevention of constipation has not been well documented. However, extensive experience with its use has documented its safety and tolerability. <br />
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Docusate has been in use in the U.S. since the 1950s and current indications are for treatment and prevention of constipation. <br />
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Docusate is available without prescription in capsules of 50, 100, 240 and 250 mg generically and under various brand names such as [[Colace]], [[Doxidan]], [[Regulex]], [[Silace]] and [[Surfak]]. A liquid formulation for oral use is also available. <br />
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The typical oral dose is 50 to 300 mg daily until bowel movements are normal. <br />
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Common side effects include diarrhea, abdominal cramping, nausea, bitter taste and dizziness.<br />
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