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			<gallery>
			File:Heart_diasystole.svg\|Heart during diastole
			File:Systolevs_Diastole.png\|Comparison of systole and diastole
			File:Wiggers_Diagram.svg\|Wiggers diagram showing cardiac cycle
			</gallery>

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'''Diastole''' is the part of the [[cardiac cycle]] when the [[heart]] relaxes and fills with [[blood]]. This occurs between [[contractions]] (systole), specifically between the [[S2 (heart sound)|second]] and [[S1 (heart sound)|first]] heart sounds. It is the longest phase of the cardiac cycle and includes both early diastole, when the [[ventricles]] first relax and start to fill; and late diastole, when the ventricles complete filling with blood from the [[atria]].

==Phases of Diastole==
Diastole is divided into four phases: isovolumetric relaxation, rapid filling, diastasis, and atrial contraction.

===Isovolumetric Relaxation===
This is the initial phase of diastole. During this phase, the [[ventricles]] begin to relax and the pressure within the ventricles drops. The [[aortic valve]] and [[pulmonary valve]] close to prevent the backflow of blood into the ventricles. The [[mitral valve]] and [[tricuspid valve]] are also closed at this time, so no blood is entering the ventricles, hence the term "isovolumetric".

===Rapid Filling===
In the rapid filling phase, the pressure in the [[atria]] becomes higher than the pressure in the ventricles. This causes the mitral and tricuspid valves to open, allowing blood to flow into the ventricles. This phase is called "rapid filling" because it is the phase where the ventricles fill the fastest.

===Diastasis===
Diastasis is a slower filling phase that occurs before the atria contract. During this phase, blood continues to flow into the ventricles, but at a slower rate.

===Atrial Contraction===
The final phase of diastole is atrial contraction. During this phase, the atria contract, pushing the remaining blood into the ventricles. This phase is also known as "atrial kick" because it provides the final push of blood to fill the ventricles before the next contraction.

==Clinical Significance==
Abnormalities in diastole can lead to [[diastolic heart failure]], where the heart is unable to fill properly. This can result in symptoms such as [[shortness of breath]], [[fatigue]], and [[edema]]. Diastolic dysfunction can be caused by conditions such as [[hypertension]], [[coronary artery disease]], and [[aging]].

==See Also==
* [[Systole]]
* [[Cardiac cycle]]
* [[Heart sounds]]
* [[Heart failure]]

==References==
<references />

[[Category:Cardiology]]
[[Category:Medical terminology]]
{{stub}}

Diastole - Revision history

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Prab: CSV import