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	~~'''~~Dextrothyroxine''' ('''D-thyroxine''') is a synthetic form of the [[thyroid hormone]] thyroxine (T4), designed as the right-handed (dextro) isomer of the naturally occurring hormone, which is the left-handed (levo) isomer. Unlike the naturally occurring form, dextrothyroxine has been found to have different effects on the body, which has led to its investigation for various clinical uses. However, it is not commonly used in current medical practice.		{{DISPLAYTITLE:Dextrothyroxine}}

	==~~Medical Uses~~==		== Dextrothyroxine ==
	Dextrothyroxine was ~~primarily investigated~~ for ~~its potential~~ in ~~treating~~ [[~~hypercholesterolemia~~]] ~~due to its ability to lower~~ [[~~cholesterol~~]] ~~levels. In~~ the ~~past, it was also explored as a treatment for~~ [[~~hypothyroidism~~]], ~~but~~ it ~~was found to be less effective and less desirable compared~~ to ~~levothyroxine,~~ the ~~standard treatment for hypothyroidism~~.		[[File:Dextrothyroxine_skeletal.svg\|thumb\|right\|Chemical structure of Dextrothyroxine]]
			'''Dextrothyroxine''' is a synthetic [[thyroid hormone]] analog that was developed for the treatment of [[hyperlipidemia]], a condition characterized by elevated levels of lipids in the blood. Unlike the naturally occurring [[thyroid hormone]] [[levothyroxine]], dextrothyroxine is the [[dextrorotatory]] isomer, meaning it rotates plane-polarized light to the right.

	==Mechanism of Action==		== Mechanism of Action ==
	~~The mechanism of action of dextrothyroxine is similar to that of~~ the ~~natural thyroid hormones. Thyroid hormones are crucial for the regulation of metabolism,~~ and ~~they exert their effects by entering cells and affecting~~ the ~~transcription~~ of ~~genes, thereby modulating~~ the ~~synthesis of various proteins~~. ~~However~~, ~~the exact mechanism by which~~ dextrothyroxine ~~lowers~~ cholesterol levels is ~~not fully understood. It is believed~~ to ~~involve modulation of lipid metabolism in the liver~~.		Dextrothyroxine functions by increasing the [[metabolic rate]] and enhancing the breakdown of [[lipids]] in the body. It acts on the [[thyroid hormone receptor]]s, although with less potency compared to [[levothyroxine]]. The primary effect of dextrothyroxine is to lower [[cholesterol]] levels, particularly [[low-density lipoprotein]] (LDL) cholesterol, which is often referred to as "bad cholesterol."

	==~~Side Effects~~==		== Clinical Use ==
	~~The~~ use ~~of dextrothyroxine can lead~~ to ~~several~~ side effects, ~~particularly when used in high doses. These may include symptoms of~~ [[~~hyperthyroidism~~]] ~~such as weight loss, increased heart rate, anxiety,~~ and ~~insomnia. Due to its effects on cholesterol and lipid metabolism~~, ~~there may also be impacts on cardiovascular health~~.		Dextrothyroxine was initially investigated for its potential to treat [[hypercholesterolemia]] and other forms of [[dyslipidemia]]. However, its use has been limited due to concerns about [[cardiovascular]] side effects, such as [[tachycardia]] and [[arrhythmias]], which are associated with excessive thyroid hormone activity.

	==~~History~~==		== Side Effects ==
	~~Dextrothyroxine's potential for treating hypercholesterolemia was explored in the mid-20th century. However~~, ~~subsequent studies revealed that the benefits might not outweigh the risks~~, ~~particularly concerning cardiovascular health~~. ~~Its~~ use has ~~significantly declined since then, with more effective and safer treatments for cholesterol management, such as statins, becoming available~~.		The side effects of dextrothyroxine are similar to those of other thyroid hormones and can include symptoms of [[hyperthyroidism]], such as increased heart rate, [[anxiety]], [[insomnia]], and [[weight loss]]. Due to these potential adverse effects, its use in clinical practice has been largely discontinued.

	==~~Current Status~~==		== History ==
	As of ~~now~~, ~~dextrothyroxine is not widely used in clinical practice. Its role in modern medicine is limited~~, ~~with research into~~ its use ~~being largely historical. The focus has shifted towards other treatments that offer better efficacy and safety profiles for the conditions dextrothyroxine was once considered for~~.		Dextrothyroxine was developed in the mid-20th century as researchers sought alternatives to traditional lipid-lowering therapies. Despite its initial promise, the development of more effective and safer lipid-lowering agents, such as [[statins]], has overshadowed its use.

	==~~See Also~~==		== Related Pages ==
	* [[Thyroid hormone]]		* [[Thyroid hormone]]
	* [[Hypercholesterolemia]]
	* [[Hypothyroidism]]
	* [[Levothyroxine]]		* [[Levothyroxine]]
			* [[Hyperlipidemia]]
			* [[Cholesterol]]
			* [[Statins]]

	[[Category:Thyroid]]		[[Category:Thyroid hormones]]
	[[Category:~~Endocrinology~~]]		[[Category:Hypolipidemic agents]]
	~~[[Category:Obsolete drugs]]~~

	~~{{Medicine-stub}}~~

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'''Dextrothyroxine''' ('''D-thyroxine''') is a synthetic form of the [[thyroid hormone]] thyroxine (T4), designed as the right-handed (dextro) isomer of the naturally occurring hormone, which is the left-handed (levo) isomer. Unlike the naturally occurring form, dextrothyroxine has been found to have different effects on the body, which has led to its investigation for various clinical uses. However, it is not commonly used in current medical practice.

==Medical Uses==
Dextrothyroxine was primarily investigated for its potential in treating [[hypercholesterolemia]] due to its ability to lower [[cholesterol]] levels. In the past, it was also explored as a treatment for [[hypothyroidism]], but it was found to be less effective and less desirable compared to levothyroxine, the standard treatment for hypothyroidism.

==Mechanism of Action==
The mechanism of action of dextrothyroxine is similar to that of the natural thyroid hormones. Thyroid hormones are crucial for the regulation of metabolism, and they exert their effects by entering cells and affecting the transcription of genes, thereby modulating the synthesis of various proteins. However, the exact mechanism by which dextrothyroxine lowers cholesterol levels is not fully understood. It is believed to involve modulation of lipid metabolism in the liver.

==Side Effects==
The use of dextrothyroxine can lead to several side effects, particularly when used in high doses. These may include symptoms of [[hyperthyroidism]] such as weight loss, increased heart rate, anxiety, and insomnia. Due to its effects on cholesterol and lipid metabolism, there may also be impacts on cardiovascular health.

==History==
Dextrothyroxine's potential for treating hypercholesterolemia was explored in the mid-20th century. However, subsequent studies revealed that the benefits might not outweigh the risks, particularly concerning cardiovascular health. Its use has significantly declined since then, with more effective and safer treatments for cholesterol management, such as statins, becoming available.

==Current Status==
As of now, dextrothyroxine is not widely used in clinical practice. Its role in modern medicine is limited, with research into its use being largely historical. The focus has shifted towards other treatments that offer better efficacy and safety profiles for the conditions dextrothyroxine was once considered for.

==See Also==
* [[Thyroid hormone]]
* [[Hypercholesterolemia]]
* [[Hypothyroidism]]
* [[Levothyroxine]]

[[Category:Thyroid]]
[[Category:Endocrinology]]
[[Category:Obsolete drugs]]

{{Medicine-stub}}

Dextrothyroxine - Revision history

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