https://wikimd.org/index.php?action=history&feed=atom&title=DextropropoxypheneDextropropoxyphene - Revision history2026-04-26T23:33:16ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.org/index.php?title=Dextropropoxyphene&diff=6319792&oldid=prevPrab: CSV import2025-02-18T04:59:23Z<p>CSV import</p>
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</table>Prabhttps://wikimd.org/index.php?title=Dextropropoxyphene&diff=5382746&oldid=prevPrab: CSV import2024-03-10T20:17:11Z<p>CSV import</p>
<p><b>New page</b></p><div>'''Dextropropoxyphene''' is a [[narcotic analgesic]] that was previously used in the treatment of mild to moderate [[pain]]. It is a synthetic [[opioid]] that is structurally related to [[methadone]]. Dextropropoxyphene was withdrawn from the market in many countries, including the United States, due to concerns about its safety and effectiveness.<br />
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== Pharmacology ==<br />
Dextropropoxyphene acts primarily as a [[mu-opioid receptor]] agonist. It also has weak [[Norepinephrine reuptake inhibitor|norepinephrine reuptake inhibiting]] properties. The drug is metabolized in the liver, primarily by the [[cytochrome P450]] enzyme system, and its metabolites are excreted in the urine.<br />
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== Medical uses ==<br />
Dextropropoxyphene was used for the relief of mild to moderate pain, either alone or in combination with [[acetaminophen]] (paracetamol) or [[aspirin]]. It was also used as a [[cough suppressant]] and an [[antidiarrheal]] agent.<br />
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== Side effects ==<br />
Common side effects of dextropropoxyphene include [[dizziness]], [[sedation]], [[nausea]], and [[vomiting]]. More serious side effects can include [[respiratory depression]], [[cardiac arrhythmia]], and [[seizure]]s. Overdose can lead to severe respiratory depression and death.<br />
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== History ==<br />
Dextropropoxyphene was first synthesized in the United States in the 1950s. It was marketed under various brand names, including Darvon and Dolene. In 2010, the [[Food and Drug Administration|FDA]] requested that all products containing dextropropoxyphene be withdrawn from the market due to concerns about the drug's safety and effectiveness.<br />
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== See also ==<br />
* [[List of withdrawn drugs]]<br />
* [[Opioid epidemic]]<br />
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[[Category:Analgesics]]<br />
[[Category:Opioids]]<br />
[[Category:Withdrawn drugs]]<br />
[[Category:Mu-opioid agonists]]<br />
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