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	~~'''~~Deoxymethoxetamine''' ('''DMXE''') is a [[dissociative]] [[psychoactive drug]] that is structurally related to [[methoxetamine]] and [[dextromethorphan]]. It is a potent [[NMDA receptor antagonist]] and [[serotonin reuptake inhibitor]], which means it can produce a range of [[psychedelic]] and [[dissociative]] effects when consumed.		== Deoxymethoxetamine ==

	~~==Chemistry==~~		[[File:DMXE_structure.svg\|thumb\|right\|Chemical structure of Deoxymethoxetamine]]

	Deoxymethoxetamine is a member of the [[arylcyclohexylamine]] class of ~~[[dissociative anesthetics]]~~. ~~Other members of this class include [[ketamine]], [[phencyclidine]] (PCP), and~~ [[methoxetamine]] (MXE)~~. The chemical structure of DMXE consists of a [[phenyl ring]] bonded to a [[cyclohexane]] ring, with an [[amino]] group attached to the cyclohexane ring. The phenyl ring~~ is ~~substituted at R3 with a~~ [[~~methoxy~~]] ~~group~~.		'''Deoxymethoxetamine''' (DMXE) is a dissociative anesthetic and a member of the [[arylcyclohexylamine]] class of compounds. It is chemically related to [[methoxetamine]] (MXE) and is known for its [[NMDA receptor antagonist]] properties.

	==~~Pharmacology~~==		== Chemical Structure and Properties ==

	~~DMXE acts primarily as an [[NMDA receptor antagonist]]. This means it blocks~~ the ~~action~~ of ~~the [[neurotransmitter]] [[glutamate]] at the NMDA receptor, which is involved in [[learning]], [[memory]], and [[neuroplasticity]]~~. DMXE ~~also acts as~~ a ~~[[serotonin reuptake inhibitor]]~~, which ~~can increase the levels~~ of ~~[[serotonin]] in the brain and produce [[mood]]-enhancing effects~~.		Deoxymethoxetamine is structurally similar to methoxetamine, with the primary difference being the absence of a methoxy group. The chemical structure of DMXE is characterized by a cyclohexane ring bound to an aryl group and an amine group, which is typical of arylcyclohexylamines.

	==~~Effects~~==		== Pharmacology ==

	~~The effects of~~ DMXE ~~can vary widely depending on the dose, the individual's physiology, and the context in which it is used. At lower doses, effects may include~~ [[~~euphoria~~]], ~~[[altered perception]], and [[increased sociability]]~~. ~~At higher doses~~, DMXE ~~can produce profound~~ [[~~dissociation]], [[hallucinations~~]], and ~~[[out-of-body experiences]]~~.		DMXE acts primarily as an [[NMDA receptor antagonist]], which leads to its dissociative effects. By inhibiting the NMDA receptor, DMXE disrupts the normal function of the [[glutamate]] neurotransmitter system, which is crucial for synaptic plasticity and memory function.

	==~~Risks and Safety~~==		== Effects ==

	~~As with all psychoactive substances, there~~ are ~~risks associated with the use~~ of ~~DMXE. These can include~~ [[~~psychological dependence~~]], ~~[[tolerance]]~~, and ~~[[withdrawal symptoms]] with regular use~~. ~~There is also the risk~~ of ~~[[overdose]], which~~ can ~~result in severe [[respiratory depression]], [[unconsciousness]],~~ and ~~death~~.		The effects of DMXE are similar to those of other dissociative anesthetics, such as [[ketamine]] and methoxetamine. Users report feelings of detachment from the environment and self, altered sensory perceptions, and euphoria. The intensity and duration of these effects can vary based on dosage and individual metabolism.

	==Legal Status==		== Legal Status ==

	The legal status of DMXE varies by country. In some ~~countries~~, it is a controlled substance~~, while in others it is legal~~ to ~~possess~~ and use.		The legal status of DMXE varies by country. In some jurisdictions, it may be classified as a controlled substance due to its potential for abuse and lack of medical use. It is important to consult local regulations to determine the legal status of DMXE in a specific area.

	==~~See Also~~==		== Related Compounds ==

	* [[~~Dissociative~~]]		* [[Methoxetamine]] (MXE)
	* [[~~Psychedelic~~ drug]]		* [[Ketamine]]
			* [[Phencyclidine]] (PCP)

			== See Also ==

			* [[Dissociative drug]]
	* [[NMDA receptor antagonist]]		* [[NMDA receptor antagonist]]
	* [[~~Serotonin reuptake inhibitor~~]]		* [[Arylcyclohexylamine]]

			== Related Pages ==

	[[~~Category:~~Psychoactive ~~drugs~~]]		* [[Psychoactive drug]]
	[[~~Category:Dissociatives~~]]		* [[Neurotransmitter]]
	[[~~Category:NMDA receptor antagonists]]~~		* [[Receptor antagonist]]
	~~[[Category:Serotonin reuptake inhibitors~~]]

	~~{{Psychoactive substance}}~~		[[Category:Dissociative drugs]]
	~~{{medicine-stub}}~~		[[Category:Arylcyclohexylamines]]

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'''Deoxymethoxetamine''' ('''DMXE''') is a [[dissociative]] [[psychoactive drug]] that is structurally related to [[methoxetamine]] and [[dextromethorphan]]. It is a potent [[NMDA receptor antagonist]] and [[serotonin reuptake inhibitor]], which means it can produce a range of [[psychedelic]] and [[dissociative]] effects when consumed.

==Chemistry==

Deoxymethoxetamine is a member of the [[arylcyclohexylamine]] class of [[dissociative anesthetics]]. Other members of this class include [[ketamine]], [[phencyclidine]] (PCP), and [[methoxetamine]] (MXE). The chemical structure of DMXE consists of a [[phenyl ring]] bonded to a [[cyclohexane]] ring, with an [[amino]] group attached to the cyclohexane ring. The phenyl ring is substituted at R3 with a [[methoxy]] group.

==Pharmacology==

DMXE acts primarily as an [[NMDA receptor antagonist]]. This means it blocks the action of the [[neurotransmitter]] [[glutamate]] at the NMDA receptor, which is involved in [[learning]], [[memory]], and [[neuroplasticity]]. DMXE also acts as a [[serotonin reuptake inhibitor]], which can increase the levels of [[serotonin]] in the brain and produce [[mood]]-enhancing effects.

==Effects==

The effects of DMXE can vary widely depending on the dose, the individual's physiology, and the context in which it is used. At lower doses, effects may include [[euphoria]], [[altered perception]], and [[increased sociability]]. At higher doses, DMXE can produce profound [[dissociation]], [[hallucinations]], and [[out-of-body experiences]].

==Risks and Safety==

As with all psychoactive substances, there are risks associated with the use of DMXE. These can include [[psychological dependence]], [[tolerance]], and [[withdrawal symptoms]] with regular use. There is also the risk of [[overdose]], which can result in severe [[respiratory depression]], [[unconsciousness]], and death.

==Legal Status==

The legal status of DMXE varies by country. In some countries, it is a controlled substance, while in others it is legal to possess and use.

==See Also==

* [[Dissociative]]
* [[Psychedelic drug]]
* [[NMDA receptor antagonist]]
* [[Serotonin reuptake inhibitor]]

[[Category:Psychoactive drugs]]
[[Category:Dissociatives]]
[[Category:NMDA receptor antagonists]]
[[Category:Serotonin reuptake inhibitors]]

{{Psychoactive substance}}
{{medicine-stub}}

Deoxymethoxetamine - Revision history

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