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Decay-accelerating factor - Revision history
2026-05-09T22:22:16Z
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Prab at 17:19, 18 March 2025
2025-03-18T17:19:46Z
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2025-03-17T09:09:42Z
<p>CSV import</p>
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2025-02-10T13:43:07Z
<p>CSV import</p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 13:43, 10 February 2025</td>
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2025-02-10T13:27:52Z
<p>CSV import</p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 13:27, 10 February 2025</td>
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Prab
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2024-02-22T01:08:40Z
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<p><b>New page</b></p><div>'''Decay-accelerating factor''' (DAF), also known as '''CD55''' or '''Cromer blood group system''', is a protein that in humans is encoded by the CD55 gene. DAF regulates the complement system on the cell surface to prevent the assembly of the complement membrane attack complex (MAC) on host cells.<br />
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== Function ==<br />
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[[Decay-accelerating factor]] is involved in the regulation of the [[complement cascade]]. It protects cells from complement-mediated injury by inhibiting the C3 convertases, C4b2a and C3bBb, and by disrupting the function of these convertases.<br />
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== Clinical significance ==<br />
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Deficiency of DAF can lead to [[paroxysmal nocturnal hemoglobinuria]] (PNH), a rare, acquired, potentially life-threatening disease of the blood characterized by complement-mediated intravascular hemolysis.<br />
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== Interactions ==<br />
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Decay-accelerating factor has been shown to [[Protein-protein interaction|interact]] with [[Complement component 3]] and [[Complement component 4b]].<br />
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== See also ==<br />
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* [[Complement system]]<br />
* [[Paroxysmal nocturnal hemoglobinuria]]<br />
* [[Complement component 3]]<br />
* [[Complement component 4b]]<br />
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== References ==<br />
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<references /><br />
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== External links ==<br />
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* [https://www.wikimd.com/wiki/Decay-accelerating_factor Decay-accelerating factor] at WikiMD<br />
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{{stub}}<br />
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[[Category:Proteins]]<br />
[[Category:Complement system]]<br />
[[Category:Blood]]<br />
[[Category:Genes]]<br />
[[Category:Medical terminology]]</div>
Prab