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Dactolisib - Revision history
2026-05-12T23:05:30Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 02:01, 17 February 2025</td>
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<p><b>New page</b></p><div>'''Dactolisib''' (also known as '''BEZ235''') is an experimental drug candidate for the treatment of various types of cancer. It is a dual [[PI3K inhibitor]] and [[mTOR inhibitor]] and has been shown to inhibit both [[phosphoinositide 3-kinase]] (PI3K) and [[mammalian target of rapamycin]] (mTOR) in preclinical studies.<br />
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== Mechanism of Action ==<br />
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Dactolisib works by inhibiting the PI3K/AKT/mTOR pathway, which is often overactive in many types of cancer. This pathway is involved in cell growth, proliferation, and survival. By inhibiting this pathway, Dactolisib can potentially slow down or stop the growth of cancer cells.<br />
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== Clinical Trials ==<br />
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Dactolisib has been tested in several [[clinical trials]] for various types of cancer, including [[breast cancer]], [[lung cancer]], and [[renal cell carcinoma]]. However, the results have been mixed, and further research is needed to determine the effectiveness and safety of this drug.<br />
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== Side Effects ==<br />
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Like all drugs, Dactolisib can cause side effects. The most common side effects reported in clinical trials include [[nausea]], [[vomiting]], [[diarrhea]], and [[fatigue]]. More serious side effects can include [[hyperglycemia]], [[pneumonitis]], and [[rash]].<br />
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== Future Research ==<br />
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While Dactolisib has shown promise in preclinical studies and early-phase clinical trials, more research is needed to determine its effectiveness and safety in larger populations of patients. Future research may also explore the potential of Dactolisib in combination with other cancer treatments.<br />
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== See Also ==<br />
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* [[PI3K inhibitor]]<br />
* [[mTOR inhibitor]]<br />
* [[Clinical trial]]<br />
* [[Cancer]]<br />
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[[Category:Experimental drugs]]<br />
[[Category:Cancer treatments]]<br />
[[Category:PI3K inhibitors]]<br />
[[Category:mTOR inhibitors]]<br />
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