https://wikimd.org/index.php?action=history&feed=atom&title=DVL1DVL1 - Revision history2026-04-25T14:21:41ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.org/index.php?title=DVL1&diff=5787274&oldid=prevPrab: CSV import2024-05-16T03:38:37Z<p>CSV import</p>
<p><b>New page</b></p><div>[[File:Protein_DVL1_PDB_1fsh.png|thumb|Protein DVL1 PDB 1fsh]] '''DVL1'''<br />
'''Dishevelled segment polarity protein 1''' (DVL1) is a protein that in humans is encoded by the DVL1 gene. DVL1 is a member of the Dishevelled family and plays a crucial role in the Wnt signaling pathway.<br />
== Structure ==<br />
DVL1 consists of three domains: DIX domain, PDZ domain, and DEP domain. These domains are essential for its function in transducing the Wnt signal.<br />
== Function ==<br />
DVL1 acts as a key mediator in the Wnt signaling pathway by transducing the signal from the cell surface receptor to the nucleus. It regulates various cellular processes such as cell proliferation, differentiation, and migration.<br />
== Clinical Significance ==<br />
Mutations in the DVL1 gene have been associated with various diseases, including cancer and developmental disorders. Dysregulation of the Wnt signaling pathway due to abnormal DVL1 function can lead to tumorigenesis and other pathological conditions.<br />
== Interactions ==<br />
DVL1 interacts with several proteins involved in the Wnt signaling pathway, such as Frizzled receptors and β-catenin. These interactions are crucial for the proper transmission of the Wnt signal within the cell.<br />
== Regulation ==<br />
The activity of DVL1 is tightly regulated by various mechanisms, including phosphorylation and protein degradation. These regulatory processes ensure the precise control of Wnt signaling in normal cellular functions.<br />
== References ==<br />
{{food-stub}}<br />
[[Category:Proteins]]<br />
[[Category:Cell biology]]<br />
[[Category:Genes]]<br />
[[Category:Wnt signaling pathway]]</div>Prab