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<p></p> <p><b>New page</b></p><div>&#039;&#039;&#039;DU145&#039;&#039;&#039; is a [[cell line]] derived from a [[brain metastasis]] of a human [[prostate cancer]] patient. This cell line is commonly used in [[cancer research]] to study the biology of prostate cancer and to test new therapeutic strategies.<br /> [[File:Apoptosis DU145 cells mosaic.jpg|thumb|[[Apoptosis]] in DU145 prostate cancer cells, induced by [[etoposide]].]]<br /> == History ==<br /> <br /> The DU145 cell line was established in the 1970s from a brain metastasis of a 69-year-old Caucasian male with prostate cancer. The cell line has been used extensively in research since its establishment.<br /> <br /> == Characteristics ==<br /> <br /> DU145 cells are [[androgen]]-independent, meaning they can grow without the presence of androgens, which are hormones that usually stimulate the growth of prostate cancer cells. This makes DU145 a useful model for studying advanced stages of prostate cancer that no longer respond to [[hormone therapy]].<br /> <br /> DU145 cells also lack the [[androgen receptor]], a protein that binds to androgens and regulates gene expression. This is another characteristic that makes DU145 a good model for studying hormone-refractory prostate cancer.<br /> <br /> == Use in Research ==<br /> <br /> DU145 cells are used in a variety of research applications. They are often used to study the biology of prostate cancer, including the mechanisms of [[tumor growth]] and [[metastasis]]. They are also used to test new therapeutic strategies, including [[chemotherapy]], [[radiation therapy]], and [[targeted therapy]].<br /> <br /> == See Also ==<br /> <br /> * [[LNCaP]]<br /> * [[PC-3]]<br /> * [[Prostate cancer]]<br /> <br /> == References ==<br /> &lt;references /&gt;<br /> <br /> [[Category:Cell lines]]<br /> [[Category:Prostate cancer]]<br /> [[Category:Cancer research]]<br /> <br /> {{stub}}</div>

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