https://wikimd.org/index.php?action=history&feed=atom&title=DNA_polymerase_lambda DNA polymerase lambda - Revision history 2026-05-14T18:02:41Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.org/index.php?title=DNA_polymerase_lambda&diff=6502594&oldid=prev Prab: CSV import 2025-03-17T08:31:23Z <p>CSV import</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 08:31, 17 March 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l23">Line 23:</td> <td colspan="2" class="diff-lineno">Line 23:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; 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color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 12:56, 10 February 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l21">Line 21:</td> <td colspan="2" class="diff-lineno">Line 21:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{DNA repair}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{DNA repair}}</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; 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(&#039;&#039;&#039;Pol λ&#039;&#039;&#039;) is a [[DNA polymerase]] enzyme found in [[eukaryotes]], including humans. It is involved in [[DNA repair]] and [[V(D)J recombination]], playing a critical role in maintaining the integrity of the genome. Pol λ belongs to the X family of DNA polymerases, which also includes [[DNA polymerase beta|Pol β]] and [[Terminal deoxynucleotidyl transferase|TdT]].<br /> <br /> == Function ==<br /> DNA polymerase lambda is versatile, participating in various DNA repair pathways, notably [[base excision repair]] (BER) and [[non-homologous end joining]] (NHEJ). In BER, Pol λ can fill in the gaps left after damaged bases are removed. During NHEJ, which repairs double-strand breaks, Pol λ can add nucleotides to the DNA ends, facilitating their rejoining.<br /> <br /> == Structure ==<br /> The enzyme consists of several domains: a polymerase domain, which synthesizes new DNA strands; a [[BRCT domain]], involved in protein-protein interactions; and a proline-rich domain, which may interact with other components of the DNA repair machinery. The structure of Pol λ allows it to interact with both DNA and other proteins involved in repair processes, enhancing its efficiency and versatility in DNA repair.<br /> <br /> == Clinical Significance ==<br /> Mutations in the POLλ gene can lead to genomic instability and contribute to the development of cancer. Given its role in DNA repair, Pol λ is also a potential target for cancer therapy. Inhibitors of Pol λ could sensitize cancer cells to DNA-damaging agents, making it a promising avenue for research.<br /> <br /> == Evolution ==<br /> Pol λ is evolutionarily conserved across eukaryotes, indicating its essential role in DNA repair. Comparative studies of Pol λ and other X family polymerases have provided insights into the mechanisms of DNA repair and the evolution of the DNA replication machinery.<br /> <br /> == Research ==<br /> Research on DNA polymerase lambda continues to uncover its mechanisms of action, regulation, and interaction with other proteins in the cell. Understanding Pol λ&#039;s function in DNA repair pathways is crucial for elucidating the molecular basis of genomic stability and the development of novel therapeutic strategies targeting DNA repair in cancer.<br /> <br /> [[Category:DNA replication]]<br /> [[Category:Enzymes]]<br /> [[Category:Molecular biology]]<br /> {{DNA repair}}<br /> {{Enzyme-stub}}</div> Prab