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2025-02-18T04:08:17Z

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← Older revision		Revision as of 04:08, 18 February 2025
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	[[Category:DNA]]		[[Category:DNA]]
	{{gene-stub}}		{{gene-stub}}
			== DNA_damage-inducible_transcript_3 ==
			<gallery>
			File:CHOP_protein_structure.png\|CHOP protein structure
			File:CHOP_regulatory_pathways.png\|CHOP regulatory pathways
			File:CHOP_mediates_ER_remodeling_in_beta_cells.tif\|CHOP mediates ER remodeling in beta cells
			</gallery>

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2024-02-28T20:48:45Z

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'''DNA damage-inducible transcript 3''' (also known as '''DDIT3''', '''CHOP''', '''GADD153''') is a [[gene]] that encodes a [[transcription factor]] involved in [[cellular stress]] responses. It is a member of the [[C/EBP]] family of transcription factors and is predominantly expressed in response to cellular stress, particularly [[endoplasmic reticulum stress]] and [[DNA damage]].

== Function ==
The DDIT3 protein is a transcription factor that regulates gene expression in response to cellular stress. It is involved in a variety of cellular processes, including [[apoptosis]], [[cell cycle]] regulation, and [[inflammation]]. In response to stress, DDIT3 can induce cell cycle arrest and apoptosis, thereby preventing the propagation of damaged cells.

== Role in Disease ==
Alterations in the expression or function of DDIT3 have been implicated in a variety of diseases, including [[cancer]], [[neurodegenerative diseases]], and [[metabolic disorders]]. In cancer, overexpression of DDIT3 has been associated with increased [[tumor]] growth and resistance to [[chemotherapy]]. In neurodegenerative diseases, DDIT3 has been implicated in the induction of neuronal cell death. In metabolic disorders, DDIT3 has been linked to [[insulin resistance]] and [[type 2 diabetes]].

== Research ==
Research into the role of DDIT3 in disease has led to the development of potential therapeutic strategies. For example, inhibitors of DDIT3 have been proposed as potential treatments for cancer and neurodegenerative diseases. Conversely, activators of DDIT3 have been proposed as potential treatments for metabolic disorders.

== See Also ==
* [[C/EBP]]
* [[Apoptosis]]
* [[Cell cycle]]
* [[Endoplasmic reticulum stress]]
* [[DNA damage]]

[[Category:Genes]]
[[Category:Transcription factors]]
[[Category:Cell biology]]
[[Category:DNA]]
{{gene-stub}}

DNA damage-inducible transcript 3 - Revision history

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