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			== Cytochrome_c_oxidase ==
			<gallery>
			File:Cytochrome_C_Oxidase_1OCC_in_Membrane_2.png\|Cytochrome C Oxidase 1OCC in Membrane
			File:Cmplx4.PNG\|Cmplx4
			File:Map_of_the_human_mitochondrial_genome.svg\|Map of the human mitochondrial genome
			File:Mitochondrial_electron_transport_chain_(annotated_diagram).svg\|Mitochondrial electron transport chain (annotated diagram)
			File:Komplex_IV.png\|Komplex IV
			</gallery>

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'''Cytochrome c oxidase''' (complex IV, CcO), is the last enzyme in the respiratory electron transport chain of [[mitochondria]]. It is located in the mitochondrial membrane and plays a critical role in the [[bioenergetics]] of the cell, being responsible for the final step in the [[oxidative phosphorylation]] pathway, where electrons from [[cytochrome c]] are transferred to [[oxygen]], the final electron acceptor, reducing it to water. This process is fundamental for the production of [[adenosine triphosphate]] (ATP), the cell's main energy-carrying molecule.

== Structure ==
Cytochrome c oxidase is a complex enzyme consisting of multiple subunits. In mammals, it is composed of 14 subunits, with three core subunits (I, II, and III) encoded by mitochondrial DNA, and the remaining ones by nuclear DNA. The enzyme also contains several [[metal]] centers, including two heme groups (a and a3) and two copper centers (CuA and CuB), which play crucial roles in the electron transfer process.

== Function ==
The primary function of cytochrome c oxidase is to catalyze the reduction of oxygen to water, a process that is coupled with the pumping of [[protons]] across the mitochondrial membrane. This proton gradient is then used by [[ATP synthase]] to generate ATP from ADP and inorganic phosphate. The activity of cytochrome c oxidase is tightly regulated, as the uncontrolled reduction of oxygen can lead to the production of harmful [[reactive oxygen species]] (ROS).

== Regulation ==
The activity of cytochrome c oxidase is regulated by the availability of its substrates (cytochrome c and oxygen) and by the concentration of ATP and ADP in the mitochondria. High levels of ATP inhibit the enzyme, while high levels of ADP activate it, thus linking the enzyme's activity to the energy needs of the cell.

== Clinical Significance ==
Mutations in the genes encoding cytochrome c oxidase subunits or assembly factors can lead to a group of mitochondrial diseases known as [[cytochrome c oxidase deficiency]] syndromes. These conditions are characterized by a wide range of symptoms, including muscle weakness, neurological disorders, and lactic acidosis, reflecting the enzyme's key role in cellular energy production.

== Research ==
Research on cytochrome c oxidase continues to be a vibrant field, with studies focusing on understanding its detailed mechanism of action, its regulation, and its role in disease. Insights into the enzyme's function and regulation have potential implications for the development of therapies for mitochondrial diseases and conditions associated with mitochondrial dysfunction.

[[Category:Enzymes]]
[[Category:Mitochondrial biology]]
[[Category:Respiratory system]]
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Cytochrome c oxidase - Revision history

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