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			== Cytochrome P450 ==
			<gallery>
			File:Structure_of_lanosterol_14_α-demethylase_(CYP51).png\|Structure of lanosterol 14 α-demethylase (CYP51)
			File:P450cycle.svg\|P450 cycle
			File:FeIVO_2.tif\|FeIVO
			File:Cytochrome_P450_Binding_Site.png\|Cytochrome P450 Binding Site
			</gallery>

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'''Cytochrome P450''' ('''CYP''') is a superfamily of [[enzyme|enzymes]] that play a crucial role in the [[metabolism]] of various substances in the body. These enzymes are involved in the metabolism of a wide variety of both endogenous and exogenous compounds, including [[drug|drugs]], [[toxin|toxins]], and [[hormone|hormones]].

== Function ==

The primary function of cytochrome P450 enzymes is to catalyze the [[oxidation]] of organic substances. This process involves the addition of an oxygen atom to the substance being metabolized, which often results in the substance becoming more soluble in water and therefore easier for the body to eliminate.

== Structure ==

Cytochrome P450 enzymes are [[heme]]-containing proteins. The heme group is a critical component of the enzyme's structure, as it is the site where the oxidation reactions occur. The structure of the enzyme also includes a binding site for the substance being metabolized, known as the substrate.

== Role in Drug Metabolism ==

Many drugs are metabolized by cytochrome P450 enzymes. This process can result in the activation or inactivation of the drug, depending on the specific drug and enzyme involved. The metabolism of drugs by these enzymes can also result in the formation of toxic metabolites, which can cause [[drug toxicity]].

== Genetic Variability ==

There is significant genetic variability in the cytochrome P450 superfamily. Different individuals can have different versions of the same enzyme, known as [[allele|alleles]], which can result in differences in how individuals metabolize certain substances. This variability can have important implications for drug therapy, as it can affect an individual's response to a drug.

== See Also ==

* [[Drug metabolism]]
* [[Pharmacogenomics]]
* [[Heme]]

== References ==

<references />

[[Category:Enzymes]]
[[Category:Metabolism]]
[[Category:Pharmacology]]
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Cytochrome P450 - Revision history

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