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			{{SI}}
			{{Infobox medical condition
			\| name = Combined immunodeficiencies
			\| image = [[File:Healthy_Human_T_Cell.jpg\|250px]]
			\| caption = Healthy Human T Cell
			\| field = [[Immunology]]
			\| symptoms = Increased susceptibility to [[infection]], failure to thrive
			\| complications = [[Autoimmune disease]], [[cancer]]
			\| onset = Usually in [[infancy]] or [[early childhood]]
			\| duration = Lifelong
			\| causes = Genetic mutations affecting the [[immune system]]
			\| risks = Family history of immunodeficiency
			\| diagnosis = [[Genetic testing]], [[blood test]]s, [[immunological assay]]s
			\| differential = [[Severe combined immunodeficiency]], [[HIV/AIDS]], other primary immunodeficiencies
			\| treatment = [[Bone marrow transplant]], [[immunoglobulin therapy]], [[antibiotics]]
			\| prognosis = Varies depending on severity and treatment
			\| frequency = Rare
			}}
	'''Combined Immunodeficiencies''' (CID) are a group of [[immune system]] disorders that are characterized by recurrent and severe [[infections]], often from a very young age. These conditions are caused by defects in the immune system that affect the functioning of both the [[T cells]] and [[B cells]].		'''Combined Immunodeficiencies''' (CID) are a group of [[immune system]] disorders that are characterized by recurrent and severe [[infections]], often from a very young age. These conditions are caused by defects in the immune system that affect the functioning of both the [[T cells]] and [[B cells]].

	==Overview==		==Overview==
	Combined immunodeficiencies are a group of disorders that primarily affect the immune system. These disorders are characterized by increased susceptibility to infections, particularly those caused by [[bacteria]], [[viruses]], and [[fungi]]. The immune system is composed of various types of cells that work together to defend the body against harmful substances. In people with combined immunodeficiencies, the immune system is not able to function properly, leading to recurrent and severe infections.		Combined immunodeficiencies are a group of disorders that primarily affect the immune system. These disorders are characterized by increased susceptibility to infections, particularly those caused by [[bacteria]], [[viruses]], and [[fungi]]. The immune system is composed of various types of cells that work together to defend the body against harmful substances. In people with combined immunodeficiencies, the immune system is not able to function properly, leading to recurrent and severe infections.

	==Causes==		==Causes==
	Combined immunodeficiencies are usually caused by genetic mutations that affect the development or function of the immune system. These mutations can be inherited from parents or can occur spontaneously during the development of the immune system.		Combined immunodeficiencies are usually caused by genetic mutations that affect the development or function of the immune system. These mutations can be inherited from parents or can occur spontaneously during the development of the immune system.

	==Symptoms==		==Symptoms==
	The symptoms of combined immunodeficiencies can vary widely, but they often include recurrent infections, growth delays, and an increased risk of developing autoimmune disorders or cancers. The severity of the symptoms can also vary, with some people experiencing mild symptoms and others experiencing severe and life-threatening complications.		The symptoms of combined immunodeficiencies can vary widely, but they often include recurrent infections, growth delays, and an increased risk of developing autoimmune disorders or cancers. The severity of the symptoms can also vary, with some people experiencing mild symptoms and others experiencing severe and life-threatening complications.

	==Diagnosis==		==Diagnosis==
	The diagnosis of combined immunodeficiencies is usually based on a combination of clinical findings, laboratory tests, and genetic testing. Laboratory tests can help to identify abnormalities in the immune system, while genetic testing can help to identify the specific mutation that is causing the disorder.		The diagnosis of combined immunodeficiencies is usually based on a combination of clinical findings, laboratory tests, and genetic testing. Laboratory tests can help to identify abnormalities in the immune system, while genetic testing can help to identify the specific mutation that is causing the disorder.

	==Treatment==		==Treatment==
	The treatment of combined immunodeficiencies is usually aimed at managing the symptoms and preventing complications. This can include antibiotics to treat infections, immunoglobulin therapy to boost the immune system, and in some cases, bone marrow transplantation to replace the defective immune system.		The treatment of combined immunodeficiencies is usually aimed at managing the symptoms and preventing complications. This can include antibiotics to treat infections, immunoglobulin therapy to boost the immune system, and in some cases, bone marrow transplantation to replace the defective immune system.

	==See Also==		==See Also==
	* [[Primary immunodeficiency]]		* [[Primary immunodeficiency]]
	* [[Severe combined immunodeficiency]]		* [[Severe combined immunodeficiency]]
	* [[Common variable immunodeficiency]]		* [[Common variable immunodeficiency]]

	[[Category:Immunodeficiency disorders]]		[[Category:Immunodeficiency disorders]]
	[[Category:Genetic disorders]]		[[Category:Genetic disorders]]
	[[Category:Rare diseases]]		[[Category:Rare diseases]]

	{{stub}}		{{stub}}
	~~<gallery>~~
	~~File:Healthy_Human_T_Cell.jpg~~
	~~</gallery>~~

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'''Combined Immunodeficiencies''' (CID) are a group of [[immune system]] disorders that are characterized by recurrent and severe [[infections]], often from a very young age. These conditions are caused by defects in the immune system that affect the functioning of both the [[T cells]] and [[B cells]].

==Overview==
Combined immunodeficiencies are a group of disorders that primarily affect the immune system. These disorders are characterized by increased susceptibility to infections, particularly those caused by [[bacteria]], [[viruses]], and [[fungi]]. The immune system is composed of various types of cells that work together to defend the body against harmful substances. In people with combined immunodeficiencies, the immune system is not able to function properly, leading to recurrent and severe infections.

==Causes==
Combined immunodeficiencies are usually caused by genetic mutations that affect the development or function of the immune system. These mutations can be inherited from parents or can occur spontaneously during the development of the immune system.

==Symptoms==
The symptoms of combined immunodeficiencies can vary widely, but they often include recurrent infections, growth delays, and an increased risk of developing autoimmune disorders or cancers. The severity of the symptoms can also vary, with some people experiencing mild symptoms and others experiencing severe and life-threatening complications.

==Diagnosis==
The diagnosis of combined immunodeficiencies is usually based on a combination of clinical findings, laboratory tests, and genetic testing. Laboratory tests can help to identify abnormalities in the immune system, while genetic testing can help to identify the specific mutation that is causing the disorder.

==Treatment==
The treatment of combined immunodeficiencies is usually aimed at managing the symptoms and preventing complications. This can include antibiotics to treat infections, immunoglobulin therapy to boost the immune system, and in some cases, bone marrow transplantation to replace the defective immune system.

==See Also==
* [[Primary immunodeficiency]]
* [[Severe combined immunodeficiency]]
* [[Common variable immunodeficiency]]

[[Category:Immunodeficiency disorders]]
[[Category:Genetic disorders]]
[[Category:Rare diseases]]

{{stub}}

Combined immunodeficiencies - Revision history

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