https://wikimd.org/index.php?action=history&feed=atom&title=ClotiapineClotiapine - Revision history2026-04-25T17:28:52ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.org/index.php?title=Clotiapine&diff=6308123&oldid=prevPrab: CSV import2025-02-17T02:09:34Z<p>CSV import</p>
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</table>Prabhttps://wikimd.org/index.php?title=Clotiapine&diff=5166766&oldid=prevPrab: CSV import2024-02-19T21:47:47Z<p>CSV import</p>
<p><b>New page</b></p><div>'''Clotiapine''' is an [[atypical antipsychotic]] medication. It is primarily used in the treatment of [[schizophrenia]] and other [[psychosis|psychotic disorders]]. Clotiapine was first synthesized in the 1960s and is marketed under various brand names across the world.<br />
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==Etymology==<br />
The name "Clotiapine" is derived from the chemical structure of the drug, which is a derivative of the [[dibenzothiazepine]] class of compounds. The "clotia-" prefix is a contraction of "chlorothiazepine", referring to the presence of a chlorine atom and a thiazepine ring in the molecule.<br />
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==Pharmacology==<br />
Clotiapine acts as an antagonist at various [[receptor (biochemistry)|receptor]] sites in the brain. It has high affinity for the [[serotonin]] 5-HT2A and 5-HT2C receptors, and the [[dopamine]] D1, D2, D3, and D4 receptors. It also has affinity for the [[histamine]] H1 and [[adrenergic receptor|adrenergic]] α1 receptors. The antipsychotic effects of clotiapine are thought to be primarily due to its antagonism of the D2 receptors in the [[mesolimbic pathway]], which is implicated in the pathophysiology of schizophrenia.<br />
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==Clinical Use==<br />
Clotiapine is used in the treatment of acute and chronic schizophrenia and other psychotic disorders. It is also used off-label for the treatment of [[insomnia]] and [[anxiety disorders]]. The drug has a rapid onset of action, with antipsychotic effects observed within the first week of treatment.<br />
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==Side Effects==<br />
Common side effects of clotiapine include [[sedation]], [[orthostatic hypotension]], [[dry mouth]], [[constipation]], and [[weight gain]]. Less common side effects include [[extrapyramidal symptoms]], [[tardive dyskinesia]], and [[neuroleptic malignant syndrome]].<br />
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==Related Terms==<br />
* [[Antipsychotic]]<br />
* [[Schizophrenia]]<br />
* [[Psychosis]]<br />
* [[Dopamine]]<br />
* [[Serotonin]]<br />
* [[Histamine]]<br />
* [[Adrenergic receptor]]<br />
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[[Category:Antipsychotics]]<br />
[[Category:Schizophrenia]]<br />
[[Category:Psychosis]]<br />
[[Category:Pharmacology]]<br />
[[Category:Medicine]]<br />
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