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<p>CSV import</p> <p><b>New page</b></p><div>[[File:Ciclopramine.svg|thumb|right]] &#039;&#039;&#039;Ciclopramine&#039;&#039;&#039; is a chemical compound that belongs to the class of [[tricyclic antidepressants]] (TCAs). It is primarily used in the treatment of [[depression]] and other mood disorders. Ciclopramine works by inhibiting the reuptake of certain neurotransmitters, thereby increasing their levels in the brain and improving mood.<br /> <br /> ==Pharmacology==<br /> Ciclopramine functions by blocking the reuptake of [[serotonin]] and [[norepinephrine]], two key neurotransmitters involved in mood regulation. By preventing their reabsorption into the presynaptic neuron, ciclopramine increases the concentration of these neurotransmitters in the synaptic cleft, enhancing their effects on the postsynaptic neuron.<br /> <br /> ==Medical Uses==<br /> Ciclopramine is primarily prescribed for the treatment of major [[depressive disorder]]. It may also be used off-label for other conditions such as [[anxiety disorders]], [[chronic pain]], and [[obsessive-compulsive disorder]] (OCD).<br /> <br /> ==Side Effects==<br /> Common side effects of ciclopramine include [[dry mouth]], [[constipation]], [[urinary retention]], [[blurred vision]], and [[drowsiness]]. More severe side effects can include [[cardiac arrhythmias]], [[seizures]], and [[orthostatic hypotension]]. Due to its side effect profile, ciclopramine is generally prescribed when other antidepressants are not effective.<br /> <br /> ==Contraindications==<br /> Ciclopramine should not be used in patients with a history of [[myocardial infarction]], [[arrhythmias]], or severe [[liver disease]]. It is also contraindicated in individuals who are currently taking [[monoamine oxidase inhibitors]] (MAOIs) due to the risk of serious drug interactions.<br /> <br /> ==Mechanism of Action==<br /> The primary mechanism of action of ciclopramine involves the inhibition of the reuptake of serotonin and norepinephrine. This leads to an increase in the levels of these neurotransmitters in the brain, which helps to alleviate symptoms of depression and improve mood.<br /> <br /> ==History==<br /> Ciclopramine was developed in the mid-20th century as part of the search for effective treatments for depression. It was one of the many tricyclic antidepressants that were discovered during this period.<br /> <br /> ==See Also==<br /> * [[Tricyclic antidepressant]]<br /> * [[Serotonin]]<br /> * [[Norepinephrine]]<br /> * [[Depression]]<br /> * [[Anxiety disorder]]<br /> * [[Obsessive-compulsive disorder]]<br /> <br /> ==References==<br /> {{Reflist}}<br /> <br /> ==External Links==<br /> {{No external links}}<br /> <br /> [[Category:Tricyclic antidepressants]]<br /> [[Category:Antidepressants]]<br /> [[Category:Psychiatry]]<br /> [[Category:Pharmacology]]<br /> <br /> {{medicine-stub}}</div>

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