Prab: CSV import

2025-04-06T01:17:07Z

CSV import

← Older revision		Revision as of 01:17, 6 April 2025
Line 1:		Line 1:
			{{SI}}
			{{Infobox medical condition
			\| name = Chronic recurrent multifocal osteomyelitis
			\| image = [[File:A_Bone_Scan_of_Chronic_Recurrent_Multifocal_Osteomyelitis_in_the_clavicle_bone_of_a_12_year_old_female,_April_2007.jpg\|250px]]
			\| caption = Bone scan showing CRMO in the clavicle of a 12-year-old female
			\| field = [[Rheumatology]]
			\| synonyms = CRMO, chronic nonbacterial osteomyelitis (CNO)
			\| symptoms = Bone pain, swelling, fever
			\| complications = [[Bone deformity]], [[growth disturbances]]
			\| onset = Typically in childhood or adolescence
			\| duration = Chronic, with periods of remission and exacerbation
			\| causes = Unknown, possibly [[autoimmune]]
			\| risks = Family history, genetic factors
			\| diagnosis = [[Clinical examination]], [[imaging studies]], [[biopsy]]
			\| differential = [[Infectious osteomyelitis]], [[bone tumors]], [[Langerhans cell histiocytosis]]
			\| treatment = [[Nonsteroidal anti-inflammatory drugs]], [[corticosteroids]], [[biologics]]
			\| prognosis = Variable, often improves with age
			\| frequency = Rare
			}}
	=='''Alternate names'''==		=='''Alternate names'''==
	CRMO; Multifocal osteomyelitis, chronic; Chronic multifocal osteomyelitis; CMO; Chronic nonbacterial osteomyelitis/Chronic recurrent multifocal osteomyelitis; CNO/CRMO		CRMO; Multifocal osteomyelitis, chronic; Chronic multifocal osteomyelitis; CMO; Chronic nonbacterial osteomyelitis/Chronic recurrent multifocal osteomyelitis; CNO/CRMO

	=='''Definition'''==		=='''Definition'''==
	Chronic recurrent multifocal osteomyelitis (CRMO) causes abnormal [[inflammation]] to occur in and around the bones.		Chronic recurrent multifocal osteomyelitis (CRMO) causes abnormal [[inflammation]] to occur in and around the bones.
	~~[[File:A Bone Scan of Chronic Recurrent Multifocal Osteomyelitis in the clavicle bone of a 12 year old female, April 2007.jpg\|thumb]]~~

	<youtube>		<youtube>
	title='''{{PAGENAME}}'''		title='''{{PAGENAME}}'''
Line 16:		Line 32:
	height=600		height=600
	</youtube>		</youtube>

	=='''Epidemiology'''==		=='''Epidemiology'''==

	*It can be difficult to estimate the exact number of people affected by a rare condition. Some people may go undiagnosed or may be diagnosed incorrectly. Others may not seek medical care.		*It can be difficult to estimate the exact number of people affected by a rare condition. Some people may go undiagnosed or may be diagnosed incorrectly. Others may not seek medical care.
	*The following estimates are based on the best information available in the scientific literature.		*The following estimates are based on the best information available in the scientific literature.
Line 25:		Line 39:
	*The exact number is unknown.		*The exact number is unknown.
	*Females tend to be affected more often than males.		*Females tend to be affected more often than males.

	=='''Cause'''==		=='''Cause'''==

	*The exact cause of chronic recurrent multifocal osteomyelitis (CRMO) is unknown.		*The exact cause of chronic recurrent multifocal osteomyelitis (CRMO) is unknown.
	*It is thought that genetics may play a role.		*It is thought that genetics may play a role.
	*In rare cases, CRMO can occur as part of Majeed syndrome, DIRA, or [[PAPA syndrome]]. All of these conditions occur due to a genetic variant in a single gene.		*In rare cases, CRMO can occur as part of Majeed syndrome, DIRA, or [[PAPA syndrome]]. All of these conditions occur due to a genetic variant in a single gene.

	=='''Onset'''==		=='''Onset'''==
	Symptoms usually begin in childhood but can occur at any age.		Symptoms usually begin in childhood but can occur at any age.

	=='''Signs and symptoms'''==		=='''Signs and symptoms'''==
	Symptoms may include:		Symptoms may include:

	* Bone and joint pain		* Bone and joint pain

	*Skin redness and/or swelling		*Skin redness and/or swelling
	*Inflammatory bowel disease		*Inflammatory bowel disease
	*[[Psoriasis]]		*[[Psoriasis]]
	*Blister-like lesions on the palms and/or soles of the feet ([[palmoplantar pustulosis]])		*Blister-like lesions on the palms and/or soles of the feet ([[palmoplantar pustulosis]])

	Symptoms typically start in childhood but can occur in any age. Symptoms range in severity from mild to severe. The bones most affected are the long bones, pelvis, shoulder girdle, and spine. CRMO can last from one to twenty years. In severe cases, bone deformities and fractures may occur.		Symptoms typically start in childhood but can occur in any age. Symptoms range in severity from mild to severe. The bones most affected are the long bones, pelvis, shoulder girdle, and spine. CRMO can last from one to twenty years. In severe cases, bone deformities and fractures may occur.

	For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed.		For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed.
	80%-99% of people have these symptoms		80%-99% of people have these symptoms
	Bone pain		Bone pain

	*[[Hyperostosis]](Bone overgrowth)		*[[Hyperostosis]](Bone overgrowth)
	*[[Osteomyelitis]](Bone infection)		*[[Osteomyelitis]](Bone infection)

	30%-79% of people have these symptoms		30%-79% of people have these symptoms

	*Abnormal vertebral morphology		*Abnormal vertebral morphology
	*Abnormality of epiphysis morphology(Abnormal shape of end part of bone)		*Abnormality of epiphysis morphology(Abnormal shape of end part of bone)
Line 68:		Line 71:
	*Poor appetite(Decreased appetite)		*Poor appetite(Decreased appetite)
	*Weight loss		*Weight loss

	5%-29% of people have these symptoms		5%-29% of people have these symptoms

	*Abnormality of the sacroiliac joint		*Abnormality of the sacroiliac joint
	*[[Acne]]		*[[Acne]]
Line 83:		Line 84:
	*Skin rash		*Skin rash
	*[[Vasculitis]](Inflammation of blood vessel)		*[[Vasculitis]](Inflammation of blood vessel)

	=='''Diagnosis'''==		=='''Diagnosis'''==

	*Diagnosis of chronic recurrent multifocal osteomyelitis (CRMO) is based on the symptoms, clinical exam, and imaging studies.		*Diagnosis of chronic recurrent multifocal osteomyelitis (CRMO) is based on the symptoms, clinical exam, and imaging studies.
	*Other more common conditions may need to be excluded before CRMO can be diagnosed.		*Other more common conditions may need to be excluded before CRMO can be diagnosed.
	*Sometimes a bone [[biopsy]] is necessary to remove a small piece of bone for examination under the microscope.		*Sometimes a bone [[biopsy]] is necessary to remove a small piece of bone for examination under the microscope.

	=='''Treatment'''==		=='''Treatment'''==

	*Treatment for chronic recurrent multifocal osteomyelitis (CRMO) is focused on managing the symptoms.		*Treatment for chronic recurrent multifocal osteomyelitis (CRMO) is focused on managing the symptoms.
	*Treatment may include [[Non-steroidal anti-inflammatory drug\|non-steroidal anti-inflammatory drugs]], [[corticosteroids]], and other drugs designed to control [[inflammation]] and prevent bone loss.		*Treatment may include [[Non-steroidal anti-inflammatory drug\|non-steroidal anti-inflammatory drugs]], [[corticosteroids]], and other drugs designed to control [[inflammation]] and prevent bone loss.

	{{Diseases of the musculoskeletal system and connective tissue}}		{{Diseases of the musculoskeletal system and connective tissue}}

	{{DEFAULTSORT:Chronic Recurrent Multifocal Osteomyelitis}}		{{DEFAULTSORT:Chronic Recurrent Multifocal Osteomyelitis}}
	[[Category:Bacterial diseases]]		[[Category:Bacterial diseases]]

Tpr: 1 revision imported

2021-01-18T16:37:25Z

1 revision imported

New page

=='''Alternate names'''==
CRMO; Multifocal osteomyelitis, chronic; Chronic multifocal osteomyelitis; CMO; Chronic nonbacterial osteomyelitis/Chronic recurrent multifocal osteomyelitis; CNO/CRMO

=='''Definition'''==
Chronic recurrent multifocal osteomyelitis (CRMO) causes abnormal [[inflammation]] to occur in and around the bones.
[[File:A Bone Scan of Chronic Recurrent Multifocal Osteomyelitis in the clavicle bone of a 12 year old female, April 2007.jpg|thumb]]

<youtube>
title='''{{PAGENAME}}'''
movie_url=http://www.youtube.com/v/=Yh1wGc_7qYY
&rel=1
embed_source_url=http://www.youtube.com/v/=Yh1wGc_7qYY
&rel=1
wrap = yes
width=750
height=600
</youtube>

=='''Epidemiology'''==

*It can be difficult to estimate the exact number of people affected by a rare condition. Some people may go undiagnosed or may be diagnosed incorrectly. Others may not seek medical care.
*The following estimates are based on the best information available in the scientific literature.
*These estimates can change based on new information.
*It has been estimated that about 1-2 people in 1,000,000 has chronic recurrent multifocal osteomyelitis.
*The exact number is unknown.
*Females tend to be affected more often than males.

=='''Cause'''==

*The exact cause of chronic recurrent multifocal osteomyelitis (CRMO) is unknown.
*It is thought that genetics may play a role.
*In rare cases, CRMO can occur as part of Majeed syndrome, DIRA, or [[PAPA syndrome]]. All of these conditions occur due to a genetic variant in a single gene.

=='''Onset'''==
Symptoms usually begin in childhood but can occur at any age.

=='''Signs and symptoms'''==
Symptoms may include:

* Bone and joint pain

*Skin redness and/or swelling
*Inflammatory bowel disease
*[[Psoriasis]]
*Blister-like lesions on the palms and/or soles of the feet ([[palmoplantar pustulosis]])

Symptoms typically start in childhood but can occur in any age. Symptoms range in severity from mild to severe. The bones most affected are the long bones, pelvis, shoulder girdle, and spine. CRMO can last from one to twenty years. In severe cases, bone deformities and fractures may occur.

For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed.
80%-99% of people have these symptoms
Bone pain

*[[Hyperostosis]](Bone overgrowth)
*[[Osteomyelitis]](Bone infection)

30%-79% of people have these symptoms

*Abnormal vertebral morphology
*Abnormality of epiphysis morphology(Abnormal shape of end part of bone)
*Abnormality of the metaphysis(Abnormality of the wide portion of a long bone)
*[[Arthritis]](Joint inflammation)
*Craniofacial [[osteosclerosis]]
*[[Edema]](Fluid retention)
*Elevated [[C-reactive protein]] level
*Elevated [[erythrocyte sedimentation rate]](High ESR)
*Fatigue(Tired)
*[[Osteolysis]](Breakdown of bone)
*Poor appetite(Decreased appetite)
*Weight loss

5%-29% of people have these symptoms

*Abnormality of the sacroiliac joint
*[[Acne]]
*Anemia(Low number of red blood cells or hemoglobin)
*[[Cranial nerve]] paralysis
*Fever
*[[Inflammation]] of the large intestine
*[[Palmoplantar pustulosis]]
*[[Pruritus]](Itching)
*[[Psoriasiform dermatitis]]
*[[Scoliosis]]
*Skin rash
*[[Vasculitis]](Inflammation of blood vessel)

=='''Diagnosis'''==

*Diagnosis of chronic recurrent multifocal osteomyelitis (CRMO) is based on the symptoms, clinical exam, and imaging studies.
*Other more common conditions may need to be excluded before CRMO can be diagnosed.
*Sometimes a bone [[biopsy]] is necessary to remove a small piece of bone for examination under the microscope.

=='''Treatment'''==

*Treatment for chronic recurrent multifocal osteomyelitis (CRMO) is focused on managing the symptoms.
*Treatment may include [[Non-steroidal anti-inflammatory drug|non-steroidal anti-inflammatory drugs]], [[corticosteroids]], and other drugs designed to control [[inflammation]] and prevent bone loss.

{{Diseases of the musculoskeletal system and connective tissue}}

{{DEFAULTSORT:Chronic Recurrent Multifocal Osteomyelitis}}
[[Category:Bacterial diseases]]
[[Category:Skeletal disorders]]
{{rarediseases}}
{{stub}}

Chronic recurrent multifocal osteomyelitis - Revision history

Prab: CSV import

Tpr: 1 revision imported