https://wikimd.org/index.php?action=history&feed=atom&title=Chromosome_1p_duplication 2026-04-27T11:14:29Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.org/index.php?title=Chromosome_1p_duplication&diff=2380828&oldid=prev 2021-06-09T14:54:39Z

<p>Created page with &quot;== &#039;&#039;&#039;Alternate names&#039;&#039;&#039; == Duplication 1p; Trisomy 1p; 1p duplication; 1p trisomy; Partial trisomy 1p == &#039;&#039;&#039;Definition&#039;&#039;&#039; == Chromosome 1p duplication is a chromosome abnorm...&quot;</p> <p><b>New page</b></p><div>== &#039;&#039;&#039;Alternate names&#039;&#039;&#039; ==<br /> Duplication 1p; Trisomy 1p; 1p duplication; 1p trisomy; Partial trisomy 1p<br /> <br /> == &#039;&#039;&#039;Definition&#039;&#039;&#039; ==<br /> Chromosome 1p duplication is a chromosome abnormality that occurs when there is an extra copy of genetic material on the short arm (p) of chromosome 1.<br /> [[File:Chromosome duplication.jpg|thumb]]<br /> <br /> == &#039;&#039;&#039;Cause&#039;&#039;&#039; ==<br /> This condition occurs when there is an &#039;&#039;&#039;extra copy of genetic material on the short arm (p) of chromosome 1&#039;&#039;&#039;.<br /> <br /> == &#039;&#039;&#039;Inheritance&#039;&#039;&#039; ==<br /> Most cases are&#039;&#039;&#039; not inherited&#039;&#039;&#039;, but people can pass the duplication on to their children.<br /> <br /> == &#039;&#039;&#039;Signs and symptoms&#039;&#039;&#039; ==<br /> * The severity of the condition and the signs and symptoms depend on the size and location of the duplication and which genes are involved. <br /> * Features that often occur in people with chromosome 1p duplication include [[developmental delay]], [[intellectual disability]], behavioral problems and distinctive facial features.<br /> <br /> == &#039;&#039;&#039;Diagnosis&#039;&#039;&#039; ==<br /> Chromosome disorders may be suspected in people who have developmental delays, intellectual disabilities and/or physical abnormalities. <br /> <br /> Several types of genetic tests can identify chromosome disorders: <br /> * &#039;&#039;&#039;Karyotype&#039;&#039;&#039; - a [[karyotype]] is a laboratory test that produces an image of a person&#039;s chromosomes. This test can be used to diagnose large deletions.<br /> * &#039;&#039;&#039;FISH &#039;&#039;&#039;- a laboratory technique that is used to detect and locate a specific [[DNA sequence]] on a chromosome. During [[FISH]], a chromosome is exposed to a small DNA sequence called a probe that has a fluorescent molecule attached to it. The probe sequence binds to its corresponding sequence on the chromosome. This test can be used in combination with [[karyotyping]] for deletions that are too small to be seen on karyotype, alone. However, FISH is only useful if the person ordering the test suspects there is a deletion of a specific region of 4q.<br /> * &#039;&#039;&#039;Array CGH&#039;&#039;&#039; - a technology that detects deletions that are too small to be seen on karyotype.<br /> <br /> == &#039;&#039;&#039;Treatment&#039;&#039;&#039; ==<br /> Treatment is based on the signs and symptoms present in each person.<br /> <br /> {{Chromosomal abnormalities}}<br /> [[Category:Rare syndromes]]<br /> [[Category:Autosomal duplications]]<br /> {{rarediseases}}<br /> {{stub}}</div>

Deepika vegiraju