https://wikimd.org/index.php?action=history&feed=atom&title=Chromosomal_translocationChromosomal translocation - Revision history2026-04-26T21:46:30ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.org/index.php?title=Chromosomal_translocation&diff=5497051&oldid=prevKondreddy Naveen at 21:16, 4 April 20242024-04-04T21:16:24Z<p></p>
<p><b>New page</b></p><div>'''Chromosomal translocation''' is a [[genetic]] phenomenon that involves the rearrangement of parts between nonhomologous [[chromosome|chromosomes]]. It is a type of [[chromosomal abnormality]] or [[mutation]] that can lead to various genetic disorders.<br />
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[[File:Translocation-4-20.png|thumb|Translocation-4-20]]<br />
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== Overview ==<br />
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A chromosomal translocation occurs when a segment of genetic material is moved from one chromosome to another, nonhomologous chromosome. This can happen during the process of [[meiosis]], leading to [[gamete]]s with abnormal chromosome arrangements. <br />
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== Types of Chromosomal Translocation ==<br />
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There are two main types of chromosomal translocation: reciprocal and Robertsonian.<br />
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=== Reciprocal Translocation ===<br />
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In a '''[[reciprocal translocation]]''', segments from two different chromosomes have been exchanged. This type of translocation is usually an exchange of material between nonhomologous chromosomes.<br />
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=== Robertsonian Translocation ===<br />
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A '''[[Robertsonian translocation]]''' involves the fusion of two acrocentric chromosomes at their centromeres, with loss of the short arms. This results in a single, large chromosome that contains the genetic material from both original chromosomes.<br />
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== Clinical Significance ==<br />
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Chromosomal translocations can lead to various genetic disorders, depending on the chromosomes involved and the specific genes that are disrupted. Some examples include [[chronic myelogenous leukemia]] (CML), which is associated with a reciprocal translocation between chromosomes 9 and 22, and [[Down syndrome]], which can be caused by a Robertsonian translocation involving chromosome 21.<br />
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== See Also ==<br />
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* [[Genetic recombination]]<br />
* [[Genetic disorder]]<br />
* [[Chromosome abnormality]]<br />
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== References ==<br />
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[[Category:Genetics]]<br />
[[Category:Chromosomes]]<br />
[[Category:Mutation]]<br />
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