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			<gallery>
			File:Acetylcholine.svg\|Acetylcholine molecule
			File:Henry_Hallett_Dale2.jpg\|Henry Hallett Dale
			File:1513_Mydriasis.jpg\|Mydriasis
			File:Physostigmine_Structural_Formulae.png\|Physostigmine structural formula
			File:Myasthenia.jpg\|Myasthenia
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'''Cholinergic blocking drugs''', also known as '''anticholinergics''' or '''parasympatholytics''', are a class of medications or substances that inhibit the action of the neurotransmitter [[acetylcholine]] at [[cholinergic receptors]]. These drugs are used to treat a variety of conditions, including respiratory disorders such as [[chronic obstructive pulmonary disease]] (COPD), gastrointestinal disorders, urinary incontinence, and certain neurological disorders. They work by blocking the action of acetylcholine in the [[central nervous system]] (CNS) and the [[peripheral nervous system]] (PNS), leading to a decrease in parasympathetic nervous system activity.

==Mechanism of Action==
Cholinergic blocking drugs operate by inhibiting the binding of acetylcholine to its receptors, which are classified into two main types: [[muscarinic receptors]] and [[nicotinic receptors]]. These receptors are found throughout the body, including in the heart, smooth muscles, and various glands. By blocking these receptors, anticholinergics reduce the effects of acetylcholine, leading to decreased bodily secretions, relaxation of smooth muscles, dilation of the pupils ([[mydriasis]]), and increased heart rate.

==Clinical Uses==
Cholinergic blocking drugs have a wide range of clinical applications. In the treatment of COPD and [[asthma]], they help to dilate the airways, making breathing easier. In the gastrointestinal tract, they can reduce muscle spasms, alleviate pain, and decrease secretions. Anticholinergics are also used in the management of [[Parkinson's disease]] to reduce muscle rigidity and tremors. Additionally, they are utilized in ophthalmology to dilate pupils during eye examinations and to treat certain eye conditions.

==Side Effects==
The use of cholinergic blocking drugs can lead to several side effects due to their widespread action on the cholinergic system. Common side effects include dry mouth, blurred vision, constipation, urinary retention, and confusion, especially in the elderly. In high doses, these drugs can cause delirium, hallucinations, and severe confusion.

==Examples==
Some common cholinergic blocking drugs include [[atropine]], [[scopolamine]], and [[ipratropium]]. Atropine is often used in emergency medicine to treat bradycardia (slow heart rate) and as a preoperative medication to reduce secretions. Scopolamine is used to prevent motion sickness and for postoperative nausea and vomiting. Ipratropium and its derivative, [[tiotropium]], are used in the management of respiratory conditions like COPD and asthma.

==Precautions and Contraindications==
Patients with certain conditions, such as [[glaucoma]], [[prostatic hypertrophy]], and [[myasthenia gravis]], should use cholinergic blocking drugs with caution, as these drugs can exacerbate these conditions. It is also important for patients to inform their healthcare provider of all medications they are taking to avoid potential drug interactions.

[[Category:Pharmacology]]
[[Category:Drugs]]
[[Category:Neurology]]

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Cholinergic blocking drug - Revision history

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