Prab: CSV import

2025-02-15T11:35:13Z

CSV import

← Older revision		Revision as of 11:35, 15 February 2025
Line 1:		Line 1:
	~~'''~~Chelerythrine''' is a [[benzophenanthridine]] [[alkaloid]] that is present in the plant [[Chelidonium majus]] (greater celandine). It is a potent, selective, and cell-permeable [[protein kinase C]] inhibitor. Chelerythrine has been shown to interact with [[DNA]] and [[RNA]], and has been studied for its potential anti-cancer properties.		{{DISPLAYTITLE:Chelerythrine}}

	==~~Chemistry~~==		== Chelerythrine ==
	~~Chelerythrine is a benzophenanthridine alkaloid, a class of compounds that are derived from the~~ [[~~isoquinoline~~]] ~~alkaloids. It has a planar structure, with a positively charged nitrogen atom that allows it to interact with DNA and RNA.~~		[[File:Chelerythrine_3D_ball.png\|thumb\|right\|3D ball-and-stick model of Chelerythrine]]

	~~==Biological activity==~~		'''Chelerythrine''' is a natural [[benzophenanthridine]] [[alkaloid]] found in various plant species, notably in the [[Papaveraceae]] family. It is known for its biological activity, particularly as a potent [[protein kinase C]] (PKC) inhibitor. Chelerythrine has been the subject of research due to its potential therapeutic applications, including its [[antimicrobial]], [[anti-inflammatory]], and [[anticancer]] properties.
	Chelerythrine is a ~~potent inhibitor of protein kinase C~~, ~~a family of enzymes that are involved~~ in ~~controlling~~ the ~~function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues~~. It is ~~cell-permeable~~, ~~meaning it can cross cell membranes~~ to ~~exert~~ its ~~effects~~.

	==~~Potential therapeutic uses~~==		== Chemical Structure ==
	Chelerythrine ~~has been studied for~~ its ~~potential anti-cancer properties. It has been shown to induce apoptosis, or programmed cell death~~, ~~in cancer cells~~. ~~It has also been shown to inhibit the growth~~ of ~~certain types of bacteria~~ and ~~fungi~~.		Chelerythrine is characterized by its complex polycyclic structure, which includes a benzophenanthridine skeleton. The molecular formula of chelerythrine is C21H18NO4. The structure features a methoxy group and a quaternary ammonium group, which are crucial for its biological activity.

	==~~Safety~~==		== Biological Activity ==
	~~While chelerythrine has potential therapeutic uses~~, ~~it is also toxic~~. It can ~~cause liver damage~~, ~~and~~ it is a ~~potent irritant to the eyes and skin~~.		Chelerythrine is primarily recognized for its ability to inhibit [[protein kinase C]], an enzyme that plays a critical role in several cellular processes, including cell proliferation, differentiation, and apoptosis. By inhibiting PKC, chelerythrine can modulate these processes, making it a compound of interest in cancer research.

	==~~See also~~==		=== Antimicrobial Properties ===
	* [[~~Chelidonium majus~~]]		Chelerythrine exhibits significant antimicrobial activity against a variety of [[bacteria]] and [[fungi]]. It disrupts microbial cell membranes and inhibits essential enzymes, contributing to its potential as an antimicrobial agent.

			=== Anti-inflammatory Effects ===
			The anti-inflammatory properties of chelerythrine are attributed to its ability to inhibit the production of pro-inflammatory cytokines and mediators. This makes it a candidate for the treatment of inflammatory diseases.

			=== Anticancer Potential ===
			Chelerythrine has shown promise in preclinical studies as an anticancer agent. It induces [[apoptosis]] in cancer cells by activating the [[mitochondrial pathway]] and inhibiting survival pathways. Its ability to target multiple signaling pathways makes it a compound of interest for developing new cancer therapies.

			== Pharmacokinetics ==
			The pharmacokinetics of chelerythrine involve its absorption, distribution, metabolism, and excretion. Chelerythrine is known to be rapidly absorbed and distributed in the body, but its metabolism and excretion pathways are still under investigation.

			== Safety and Toxicity ==
			While chelerythrine has demonstrated beneficial biological activities, its toxicity profile is a concern. High doses of chelerythrine can be toxic, and its safety in humans has not been fully established. Further studies are needed to determine the therapeutic window and potential side effects.

			== Related Pages ==
			* [[Benzophenanthridine]]
	* [[Protein kinase C]]		* [[Protein kinase C]]
			* [[Alkaloid]]
			* [[Antimicrobial]]
	* [[Apoptosis]]		* [[Apoptosis]]

	[[Category:Alkaloids]]		[[Category:Alkaloids]]
	[[Category:Protein kinase inhibitors]]		[[Category:Protein kinase inhibitors]]
	[[Category:~~DNA intercalators~~]]		[[Category:Antimicrobials]]

	~~{{stub}}~~

	~~==References==~~
	~~<references />~~

	~~==External links==~~
	* [https://pubchem.ncbi.nlm.nih.gov/compound/Chelerythrine PubChem Compound Summary for Chelerythrine]
	* [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269759/ Chelerythrine: A Review of Its Pharmacology, Toxicity and Anticancer Activity]

Prab: CSV import

2024-02-25T22:40:11Z

CSV import

New page

'''Chelerythrine''' is a [[benzophenanthridine]] [[alkaloid]] that is present in the plant [[Chelidonium majus]] (greater celandine). It is a potent, selective, and cell-permeable [[protein kinase C]] inhibitor. Chelerythrine has been shown to interact with [[DNA]] and [[RNA]], and has been studied for its potential anti-cancer properties.

==Chemistry==
Chelerythrine is a benzophenanthridine alkaloid, a class of compounds that are derived from the [[isoquinoline]] alkaloids. It has a planar structure, with a positively charged nitrogen atom that allows it to interact with DNA and RNA.

==Biological activity==
Chelerythrine is a potent inhibitor of protein kinase C, a family of enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues. It is cell-permeable, meaning it can cross cell membranes to exert its effects.

==Potential therapeutic uses==
Chelerythrine has been studied for its potential anti-cancer properties. It has been shown to induce apoptosis, or programmed cell death, in cancer cells. It has also been shown to inhibit the growth of certain types of bacteria and fungi.

==Safety==
While chelerythrine has potential therapeutic uses, it is also toxic. It can cause liver damage, and it is a potent irritant to the eyes and skin.

==See also==
* [[Chelidonium majus]]
* [[Protein kinase C]]
* [[Apoptosis]]

[[Category:Alkaloids]]
[[Category:Protein kinase inhibitors]]
[[Category:DNA intercalators]]

{{stub}}

==References==
<references />

==External links==
* [https://pubchem.ncbi.nlm.nih.gov/compound/Chelerythrine PubChem Compound Summary for Chelerythrine]
* [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269759/ Chelerythrine: A Review of Its Pharmacology, Toxicity and Anticancer Activity]

Chelerythrine - Revision history

Prab: CSV import

Prab: CSV import