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	~~'''~~Cell cortex''' refers to the specialized layer of cytoplasm on the inner face of the [[plasma membrane]] of [[cell (biology)\|cells]], particularly those of [[eukaryotes]]. This layer is involved in various cellular processes including shaping the cell, enabling cell movement, and division. It is rich in [[actin]] filaments and other [[cytoskeletal]] components, which are crucial for maintaining cell structure and facilitating intracellular transport.		== Cell Cortex ==

	~~==Structure==~~		[[File:Actin-cortex.png\|thumb\|right\|Diagram of the actin cortex in a cell.]]
	~~The cell cortex is typically a dynamic structure composed primarily of a meshwork of actin filaments,~~ [[~~myosin]] motor proteins, and various [[binding proteins]] that regulate the assembly and disassembly~~ of the ~~actin network. This~~ actin cortex lies just beneath the plasma membrane and is often associated with membrane-bound proteins that link the cortex to the membrane, providing structural stability and facilitating communication between the cell~~'s interior and its environment~~.

	~~==Function==~~		The '''cell cortex''' is a specialized layer of [[cytoplasm]] on the inner face of the [[plasma membrane]] in [[eukaryotic cells]]. It is primarily composed of a network of [[actin]] filaments and associated proteins, which provide structural support and play a crucial role in various cellular processes.
	The ~~functions~~ of the ~~cell cortex are diverse~~ and ~~critical for the cell's life~~. ~~These include:~~

	* '''Cell Shape and Rigidity:''' The actin-myosin network provides mechanical strength to cells, helping to maintain their shape and resist deformation.		== Structure ==
	* '''Cell Movement:''' Through the polymerization and depolymerization of actin filaments, the cell cortex can generate forces that propel the cell forward. This is essential in processes such as [[migration (biology)\|migration]], [[wound healing]], and [[embryogenesis]].
	* '''Cell Division:''' During [[mitosis]], the cell cortex plays a crucial role in cytokinesis, the final separation of the two daughter cells. It helps form the contractile ring that pinches the cell into two.
	* '''Signal Transduction:''' The cell cortex is involved in transmitting signals from the cell surface to the interior, affecting various cellular responses and activities.

	~~==Regulation==~~		The cell cortex is a dynamic structure that is closely associated with the plasma membrane. It consists of a dense meshwork of actin filaments, which are cross-linked by various actin-binding proteins. This network is often referred to as the actin cortex. The actin filaments are organized in a way that allows the cortex to maintain cell shape, resist mechanical stress, and facilitate cell movement.
	The ~~dynamics of the~~ cell cortex ~~are regulated by~~ a ~~complex interplay of signaling pathways~~ that ~~control~~ the ~~polymerization and depolymerization~~ of actin, ~~the activity of myosin motors, and the~~ binding ~~of various~~ proteins to actin filaments~~. Key players~~ in ~~this regulation include [[Rho family of GTPases]], which are master regulators of~~ the ~~actin cytoskeleton~~, ~~and [[phosphoinositides]]~~, ~~lipids that can act as signaling molecules to recruit~~ and ~~activate proteins involved in actin dynamics~~.

	==~~Clinical Significance~~==		== Function ==
	~~Abnormalities in the~~ cell cortex ~~can lead~~ to ~~a variety of diseases~~. ~~For example, defects~~ in ~~actin regulation can cause issues with~~ cell movement and ~~division~~, ~~leading to developmental disorders~~ and ~~contributing to~~ the ~~progression~~ of ~~cancer~~. ~~Understanding~~ the ~~cell~~ cortex is ~~therefore not only important for basic cell biology but also for developing therapeutic strategies for~~ a ~~range~~ of ~~diseases~~.
			The cell cortex serves several important functions:

			* '''Mechanical Support''': The cortex provides mechanical strength to the cell, helping it maintain its shape and resist deformation.
			* '''Cell Movement''': The actin cortex is involved in cell motility, enabling processes such as [[amoeboid movement]], [[cytokinesis]], and [[cell migration]].
			* '''Signal Transduction''': The cortex plays a role in signal transduction pathways, where it can influence the activity of membrane-bound receptors and other signaling molecules.
			* '''Cell Division''': During [[mitosis]], the cortex is involved in the formation of the [[contractile ring]] that facilitates the separation of daughter cells.

			== Dynamics ==

			The actin cortex is highly dynamic, with actin filaments constantly undergoing polymerization and depolymerization. This dynamic nature allows the cortex to rapidly reorganize in response to cellular signals and environmental changes. The regulation of actin dynamics is controlled by a variety of proteins, including [[formin]]s, [[Arp2/3 complex]], and [[cofilin]].

			== Related pages ==

			* [[Actin]]
			* [[Cytoskeleton]]
			* [[Plasma membrane]]
			* [[Cell motility]]
			* [[Cytokinesis]]

	[[Category:Cell biology]]		[[Category:Cell biology]]
	~~[[Category:Cytoskeleton]]~~

	~~{{Cell-biology-stub}}~~

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2024-03-23T23:42:26Z

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'''Cell cortex''' refers to the specialized layer of cytoplasm on the inner face of the [[plasma membrane]] of [[cell (biology)|cells]], particularly those of [[eukaryotes]]. This layer is involved in various cellular processes including shaping the cell, enabling cell movement, and division. It is rich in [[actin]] filaments and other [[cytoskeletal]] components, which are crucial for maintaining cell structure and facilitating intracellular transport.

==Structure==
The cell cortex is typically a dynamic structure composed primarily of a meshwork of actin filaments, [[myosin]] motor proteins, and various [[binding proteins]] that regulate the assembly and disassembly of the actin network. This actin cortex lies just beneath the plasma membrane and is often associated with membrane-bound proteins that link the cortex to the membrane, providing structural stability and facilitating communication between the cell's interior and its environment.

==Function==
The functions of the cell cortex are diverse and critical for the cell's life. These include:

* '''Cell Shape and Rigidity:''' The actin-myosin network provides mechanical strength to cells, helping to maintain their shape and resist deformation.
* '''Cell Movement:''' Through the polymerization and depolymerization of actin filaments, the cell cortex can generate forces that propel the cell forward. This is essential in processes such as [[migration (biology)|migration]], [[wound healing]], and [[embryogenesis]].
* '''Cell Division:''' During [[mitosis]], the cell cortex plays a crucial role in cytokinesis, the final separation of the two daughter cells. It helps form the contractile ring that pinches the cell into two.
* '''Signal Transduction:''' The cell cortex is involved in transmitting signals from the cell surface to the interior, affecting various cellular responses and activities.

==Regulation==
The dynamics of the cell cortex are regulated by a complex interplay of signaling pathways that control the polymerization and depolymerization of actin, the activity of myosin motors, and the binding of various proteins to actin filaments. Key players in this regulation include [[Rho family of GTPases]], which are master regulators of the actin cytoskeleton, and [[phosphoinositides]], lipids that can act as signaling molecules to recruit and activate proteins involved in actin dynamics.

==Clinical Significance==
Abnormalities in the cell cortex can lead to a variety of diseases. For example, defects in actin regulation can cause issues with cell movement and division, leading to developmental disorders and contributing to the progression of cancer. Understanding the cell cortex is therefore not only important for basic cell biology but also for developing therapeutic strategies for a range of diseases.

[[Category:Cell biology]]
[[Category:Cytoskeleton]]

{{Cell-biology-stub}}

Cell cortex - Revision history

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