Deepika vegiraju at 12:39, 19 February 2022

2022-02-19T12:39:22Z

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== '''What is Ceftaroline fosamil?''' ==

* Ceftaroline fosamil ('''Teflaro''') is a '''[[cephalosporin]] antibacterial''' used for the treatment of Acute bacterial skin and skin structure infections (ABSSSI),Community-acquired bacterial pneumonia ([[CABP]]).

[[File:Ceftaroline-fosamil-anion-3D-balls.png|thumb|Ceftaroline-fosamil-anion-3D-balls]]
[[File:Ceftaroline fosamil2DCSD.svg|thumb|Ceftaroline fosamil2DCSD]]
[[File:Ceftaroline-fosamil-anion-3D-spacefill.png|thumb|Ceftaroline-fosamil-anion-3D-spacefill]]

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== '''What are the uses of this medicine?''' ==

Ceftaroline fosamil (Teflaro) is used for the treatment of the following infection caused by designated susceptible bacteria:
* [[Acute bacterial skin and skin structure infections]] (ABSSSI) in adult and pediatric patients (at least 34 weeks gestational age and 12 days postnatal age).
* Community-acquired bacterial pneumonia ([[CABP]]) in adult and pediatric patients 2 months of age and older.

== '''How does this medicine work?''' ==

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* Ceftaroline is a [[cephalosporin]] antibacterial drug.
* Ceftaroline is a cephalosporin antibacterial drug with in vitro activity against [[Gram-positive]] and [[gram-negative]] bacteria.
* The [[bactericidal]] action of ceftaroline is mediated through binding to essential [[Penicillin-binding protein|penicillin-binding proteins]] (PBPs).
* Ceftaroline is '''bactericidal against S. aureus due to its affinity for PBP2a and against Streptococcus pneumoniae due to its affinity for PBP2x'''.

== '''Who Should Not Use this medicine ?''' ==

This medicine cannot be used in patients who:
* with known serious [[hypersensitivity]] to ceftaroline or other members of the cephalosporin class.

== '''What drug interactions can this medicine cause?''' ==

* No formal drug interaction studies have been conducted with Teflaro.

== '''Is this medicine FDA approved?''' ==

* Ceftaroline received approval from the U.S. Food and Drug Administration (FDA) for the treatment of community-acquired bacterial pneumonia and acute bacterial skin infections on 29 October 2010.

== '''How should this medicine be used?''' ==

'''Recommended dosage:'''
'''Recommended Dosage in Adult Patients:'''
* The recommended dosage of Teflaro is 600 mg administered every 12 hours by intravenous (IV) infusion over 5 to 60 minutes in patients ≥ 18 years of age.

{| class="wikitable"
|+Dosage of Teflaro by Indication in Adults
|-
! Indication !! Dosage !! Frequency !! Infusion Time!! Recommended Duration of Treatment
|-
| ABSSSI || 600 mg ||Every 12 hours || 5 to 60 minutes || 5-14 days
|-
| CABP || 600 mg || Every 12 hours || 5 to 60 minutes || 5-7 days
|}

'''Recommended Dosage in Pediatric Patients:'''
* The recommended dosage of Teflaro in pediatric patients is based on the age and weight of the child.

'''Pediatric Patients 2 Months of Age and Older:'''

{| class="wikitable"
|+ Dosage of Teflaro by Indication in Pediatric Patients 2 Months of Age and Older
|-
! Indication !! Age Range !! Dosage and Frequency!! Infusion time !! Recommended Duration of Treatment
|-
| ABSSSI or CABP ||2 months to < 2 years || 8 mg/kg every 8 hours ||5 to 60 minutes || 5-14 days
|-
| || > 2 years to < 18 years (< 33 kg)|| 12 mg/kg every 8 hours || ||
|}

'''Pediatric Patients Less Than 2 Months of Age:'''

{| class="wikitable"
|+Dosage of Teflaro in Pediatric Patients less Than 2 Months of Age
|-
! Indication !! Age Range !! Dosage and Frequency !! Infusion time !! Recommended Duration of Treatment
|-
| Acute Bacterial Skin and Skin Structure Infections (ABSSSI) || 0* to < 2 months || 6 mg/kg every 8 hours || 30 to 60 minutes|| 5-14 days
|}

'''Administration:'''
* For pediatric patients 2 months of age and older, Teflaro is administered every 8 hours by intravenous infusion over 5 to 60 minutes.
* Teflaro is administered every 8 hours by intravenous infusion over 30 to 60 minutes for patients less than 2 months of age.
* Teflaro dosing regimen is only recommended for patients with ABSSSI.

== '''What are the dosage forms and brand names of this medicine?''' ==

This medicine is available in fallowing doasage form:
*'''As Injection:''' 600 mg or 400 mg of sterile ceftaroline fosamil powder in single-dose 20 mL vials. The powder is constituted and further diluted for intravenous injection.

This medicine is available in fallowing brand namesː
*'''Teflaro'''

=='''What side effects can this medication cause?'''==

The most common side effects of this medicine include:
* diarrhea
* nausea
* rash
* vomiting
* pyrexia

==''' What special precautions should I follow?''' ==

* Serious [[hypersensitivity]] ([[anaphylactic]]) reactions have been reported with beta-lactam antibacterial drugs, including Teflaro. If a hypersensitivity reaction occurs, discontinue Teflaro.
* [[Clostridium Difficile|Clostridioides difficile-associated diarrhea]] (CDAD) has been reported with nearly all systemic antibacterial agents, including Teflaro. Evaluate if diarrhea occurs.
* Neurological adverse reactions have been reported in patients treated with [[cephalosporins]], including Teflaro. If neurological adverse reactions occur, consider discontinuing Teflaro or making appropriate dosage adjustments in patients with renal impairment.
* Direct [[Coombs test|Coombs’ test]] [[seroconversion]] has been reported with Teflaro. If anemia develops during or after therapy, a diagnostic workup for drug-induced [[hemolytic anemia]] should be performed and consideration given to discontinuation of Teflaro.

== '''What to do in case of emergency/overdose?''' ==

Symptoms of overdosage may include:
* renal impairment
* neurological sequelae
* [[encephalopathy]]

'''Management of overdosage:'''
* In the event of overdose, Teflaro should be discontinued and general supportive treatment given.
* Ceftaroline can be removed by [[hemodialysis]].
* However, no information is available on the use of hemodialysis to treat overdosage.

== '''Can this medicine be used in pregnancy?''' ==

* There are no adequate studies with Teflaro in pregnant women that informed any drug associated risks.

=='''Can this medicine be used in children?'''==

* The safety and effectiveness of Teflaro in the treatment of ABSSSI have been established in pediatric patients (at least 34 weeks gestational age and 12 days postnatal age).
* The safety and effectiveness of Teflaro in the treatment of CABP have been established in the age groups 2 months to less than 18 years old.
* Safety and effectiveness of Teflaro in pediatric patients less than 34 weeks gestational age and less than 12 days postnatal age for the treatment of ABSSSI have not been established.
* Safety and effectiveness of Teflaro in pediatric patients below the age of 2 months for the treatment of CABP have not been established as no data are available.

== '''What are the active and inactive ingredients in this medicine?''' ==

'''Active Ingredient:'''
* CEFTAROLINE FOSAMIL

'''Inactive Ingredients:'''
* ARGININE

== '''Who manufactures and distributes this medicine?''' ==

'''Distributed by:'''
[[Allergan]] USA, Inc.
Madison, NJ
Teflaro® is a registered trademark of Allergan Sales, LLC

== '''What should I know about storage and disposal of this medication?''' ==

* Teflaro vials (unreconstituted) should be stored at 25ºC (77ºF); excursions permitted to 15-30ºC (59-86ºF).

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Ceftaroline fosamil - Revision history

Deepika vegiraju at 12:39, 19 February 2022