https://wikimd.org/index.php?action=history&feed=atom&title=Cefquinome 2026-04-26T04:42:33Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.org/index.php?title=Cefquinome&diff=5368552&oldid=prev 2024-03-06T04:07:55Z

<p>CSV import</p> <p><b>New page</b></p><div>[[File:Cefquinome.png|thumb|{{PAGENAME}}]]&lt;br&gt;&#039;&#039;&#039;Cefquinome&#039;&#039;&#039; is a [[fourth-generation cephalosporin]] [[antibiotic]] primarily used in [[veterinary medicine]]. It is a broad-spectrum antibiotic that is effective against a wide range of [[Gram-positive bacteria|Gram-positive]] and [[Gram-negative bacteria]]. Cefquinome is marketed under the trade name &#039;&#039;&#039;Cobactan&#039;&#039;&#039; by [[Intervet]], a subsidiary of [[Merck &amp; Co]].<br /> <br /> ==Pharmacology==<br /> Cefquinome is a [[beta-lactam antibiotic]], which means it works by inhibiting the synthesis of the [[peptidoglycan]] layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity. The final transpeptidation step in the synthesis of the peptidoglycan is facilitated by [[transpeptidases]] known as [[penicillin-binding proteins]] (PBPs). Cefquinome binds to these PBPs and inhibits the final transpeptidation step of peptidoglycan synthesis, resulting in cell death.<br /> <br /> ==Uses==<br /> Cefquinome is used in veterinary medicine to treat a variety of infections caused by susceptible bacteria. These include [[respiratory tract infection]]s, [[mastitis]] in dairy cows, and [[foot rot]] in cattle. It is also used to treat [[septicemia]] in calves and [[swine bacterial pneumonia]].<br /> <br /> ==Side Effects==<br /> As with all antibiotics, side effects can occur with the use of cefquinome. These can include [[allergic reaction]]s, [[diarrhea]], and changes in blood counts. In animals, side effects can also include local reactions at the site of injection.<br /> <br /> ==Resistance==<br /> Resistance to cefquinome can occur through several mechanisms. These include the production of [[beta-lactamase]] enzymes that can inactivate the drug, alteration of the PBPs that the drug targets, and changes in the permeability of the bacterial cell wall that prevent the drug from reaching its target.<br /> <br /> ==See Also==<br /> * [[Cephalosporin]]<br /> * [[Antibiotic resistance]]<br /> * [[Veterinary medicine]]<br /> <br /> [[Category:Antibiotics]]<br /> [[Category:Cephalosporin antibiotics]]<br /> [[Category:Veterinary drugs]]<br /> {{Antibiotics}}<br /> {{Veterinary medicine}}<br /> {{pharmacology-stub}}</div>

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