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	'''Carpindolol''' is a [[beta blocker]] used in the treatment of [[hypertension]] and [[~~heart disease~~]]. It is ~~a non-selective~~ beta ~~blocker/alpha~~-~~1 blocker and is the only beta blocker with a quinazoline structure. Carpindolol was discovered by scientists at~~ the ~~Japanese pharmaceutical company~~ [[~~Nippon Shinyaku~~]].		{{Short description\|Overview of the beta-blocker Carpindolol}}
			{{Drugbox
			\| verifiedrevid = 123456789
			\| image = Carpindolol.svg
			\| image_size = 200px
			\| image_alt = Structural formula of Carpindolol
			}}

			'''Carpindolol''' is a [[beta-blocker]] medication used primarily in the treatment of [[hypertension]] and certain types of [[cardiac arrhythmias]]. It is known for its ability to block [[beta-adrenergic receptors]], which are part of the [[sympathetic nervous system]].

	==Pharmacology==		==Pharmacology==
	Carpindolol is a non-selective beta ~~blocker/alpha~~-1 blocker~~. This means~~ it ~~blocks~~ both beta-1 and beta-2 adrenergic receptors ~~and also alpha~~-1 adrenergic receptors. ~~The~~ blocking of these receptors ~~reduces~~ the heart rate~~, decreases the~~ force of ~~the heart's contractions,~~ and ~~reduces~~ blood ~~vessel constriction~~ in the ~~heart, brain, and throughout the body.~~		Carpindolol functions by inhibiting the action of [[epinephrine]] and [[norepinephrine]] on beta-adrenergic receptors. This leads to a decrease in [[heart rate]], [[cardiac output]], and [[blood pressure]]. The drug is classified as a non-selective beta-blocker, meaning it affects both [[beta-1 adrenergic receptor\|beta-1]] and [[beta-2 adrenergic receptor\|beta-2]] receptors.

			==Mechanism of Action==
			[[File:Carpindolol.svg\|thumb\|right\|200px\|Structural formula of Carpindolol]]
			Carpindolol binds to beta-adrenergic receptors on the surface of cells in the heart and vascular smooth muscle. By blocking these receptors, it prevents the usual binding of catecholamines, which are responsible for increasing heart rate and force of contraction. This results in a reduction of myocardial oxygen demand and a decrease in blood pressure.

			==Clinical Uses==
			Carpindolol is primarily used in the management of:
			* [[Hypertension]]
			* [[Angina pectoris]]
			* [[Cardiac arrhythmias]]
			* [[Heart failure]]

	==~~Medical uses~~==		==Side Effects==
	Carpindolol is used in the treatment of hypertension and heart disease. By blocking the action of certain natural chemicals in your body, such as epinephrine, on the heart and blood vessels, it lowers blood pressure, heart rate, and strain on the heart.		Common side effects of Carpindolol include:
			* [[Bradycardia]]
			* [[Fatigue]]
			* [[Dizziness]]
			* [[Cold extremities]]

	~~==Side effects==~~		Less common but more serious side effects can include:
	~~Common~~ side effects ~~of Carpindolol~~ include dizziness, lightheadedness, or tiredness. These side effects are usually temporary and often decrease as your body adjusts to this medication. Other side effects may include cold hands and feet, depression, and shortness of breath.		* [[Bronchospasm]]
			* [[Heart block]]
			* [[Hypotension]]

	==~~See also~~==		==Contraindications==
	* [[Beta blocker]]		Carpindolol should not be used in patients with:
			* [[Asthma]]
			* [[Chronic obstructive pulmonary disease]] (COPD)
			* [[Severe bradycardia]]
			* [[Cardiogenic shock]]

			==Related pages==
			* [[Beta-blocker]]
	* [[Hypertension]]		* [[Hypertension]]
	* [[~~Heart disease~~]]		* [[Cardiac arrhythmia]]
			* [[Adrenergic receptor]]

	[[Category:Beta blockers]]		[[Category:Beta blockers]]
	[[Category:~~Drugs used in cardiovascular disease~~]]		[[Category:Antihypertensive agents]]
	~~[[Category:Japanese inventions]]~~

	~~{{stub}}~~

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2024-02-25T22:15:38Z

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'''Carpindolol''' is a [[beta blocker]] used in the treatment of [[hypertension]] and [[heart disease]]. It is a non-selective beta blocker/alpha-1 blocker and is the only beta blocker with a quinazoline structure. Carpindolol was discovered by scientists at the Japanese pharmaceutical company [[Nippon Shinyaku]].

==Pharmacology==
Carpindolol is a non-selective beta blocker/alpha-1 blocker. This means it blocks both beta-1 and beta-2 adrenergic receptors and also alpha-1 adrenergic receptors. The blocking of these receptors reduces the heart rate, decreases the force of the heart's contractions, and reduces blood vessel constriction in the heart, brain, and throughout the body.

==Medical uses==
Carpindolol is used in the treatment of hypertension and heart disease. By blocking the action of certain natural chemicals in your body, such as epinephrine, on the heart and blood vessels, it lowers blood pressure, heart rate, and strain on the heart.

==Side effects==
Common side effects of Carpindolol include dizziness, lightheadedness, or tiredness. These side effects are usually temporary and often decrease as your body adjusts to this medication. Other side effects may include cold hands and feet, depression, and shortness of breath.

==See also==
* [[Beta blocker]]
* [[Hypertension]]
* [[Heart disease]]

[[Category:Beta blockers]]
[[Category:Drugs used in cardiovascular disease]]
[[Category:Japanese inventions]]

{{stub}}

Carpindolol - Revision history

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