https://wikimd.com/index.php?action=history&feed=atom&title=Cancer-associated_fibroblastCancer-associated fibroblast - Revision history2026-04-24T11:28:04ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.com/index.php?title=Cancer-associated_fibroblast&diff=6302240&oldid=prevPrab: CSV import2025-02-16T22:02:20Z<p>CSV import</p>
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</table>Prabhttps://wikimd.com/index.php?title=Cancer-associated_fibroblast&diff=5351477&oldid=prevPrab: CSV import2024-03-03T14:15:20Z<p>CSV import</p>
<p><b>New page</b></p><div>'''Cancer-associated fibroblasts''' (often abbreviated as '''CAF''') are a type of cell that are present within the [[tumor microenvironment]]. They are one of the most abundant cell types in many types of [[cancer]], and play a crucial role in cancer progression and metastasis.<br />
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== Overview ==<br />
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Cancer-associated fibroblasts are derived from normal [[fibroblast]]s, which are cells that produce the structural framework (stroma) for animal tissues. In response to signals from cancer cells, fibroblasts can become permanently activated and transform into CAFs. These cells then contribute to the growth and spread of the tumor by secreting various growth factors, cytokines, and extracellular matrix proteins.<br />
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== Role in Cancer Progression ==<br />
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CAFs play a key role in promoting [[tumor growth]] and [[metastasis]]. They do this through a variety of mechanisms, including:<br />
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* '''Stimulation of angiogenesis:''' CAFs secrete factors such as [[vascular endothelial growth factor]] (VEGF) and [[fibroblast growth factor]] (FGF), which promote the formation of new blood vessels. This provides the tumor with the nutrients it needs to grow.<br />
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* '''Promotion of cancer cell invasion:''' CAFs remodel the extracellular matrix and secrete enzymes that degrade the basement membrane, allowing cancer cells to invade surrounding tissues.<br />
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* '''Immune evasion:''' CAFs can suppress the immune response to the tumor by secreting immunosuppressive factors and attracting regulatory T cells.<br />
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== Therapeutic Targeting of CAFs ==<br />
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Due to their crucial role in cancer progression, CAFs are being investigated as potential therapeutic targets. Strategies for targeting CAFs include inhibiting their activation, blocking their secreted factors, or depleting them from the tumor microenvironment. However, these approaches are still in the early stages of development and further research is needed to determine their efficacy and safety.<br />
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== See Also ==<br />
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* [[Tumor microenvironment]]<br />
* [[Fibroblast]]<br />
* [[Angiogenesis]]<br />
* [[Metastasis]]<br />
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== References ==<br />
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{{reflist}}<br />
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[[Category:Cancer]]<br />
[[Category:Cell biology]]<br />
[[Category:Oncology]]<br />
{{cancer-stub}}<br />
{{cell-biology-stub}}</div>Prab