https://wikimd.org/index.php?action=history&feed=atom&title=CalretininCalretinin - Revision history2026-04-25T21:07:18ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.org/index.php?title=Calretinin&diff=6305225&oldid=prevPrab: CSV import2025-02-17T01:49:21Z<p>CSV import</p>
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<p><b>New page</b></p><div>'''Calretinin''' is a [[calcium-binding protein]] that is primarily expressed in the [[nervous system]]. It is a member of the [[EF-hand proteins]] family, which are characterized by their ability to bind [[calcium ions]]. Calretinin is used as a [[biomarker]] in the diagnosis of certain types of [[cancer]], including [[mesothelioma]] and [[ovarian cancer]].<br />
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== Structure and Function ==<br />
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Calretinin is a 29-kDa protein that contains six EF-hand motifs, four of which can bind calcium ions. The protein is encoded by the [[CALB2]] gene in humans. It is primarily located in the [[cytoplasm]] of cells, but can also be found in the [[nucleus]].<br />
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The exact function of calretinin is not fully understood. However, it is known to play a role in [[calcium signaling]], which is crucial for many cellular processes. It is also thought to be involved in [[neuronal development]] and [[neuroprotection]].<br />
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== Clinical Significance ==<br />
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Calretinin is used as a biomarker in the diagnosis of certain types of cancer. It is particularly useful in distinguishing mesothelioma from other types of [[lung cancer]], as it is expressed in the majority of mesothelioma cases but is rarely found in other lung cancers. It is also used in the diagnosis of ovarian cancer, as it is expressed in certain types of this disease.<br />
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In addition to its role in cancer diagnosis, calretinin may also have potential as a therapeutic target. Studies have suggested that inhibiting the expression of calretinin could slow the growth of mesothelioma cells.<br />
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== See Also ==<br />
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* [[Calcium-binding protein]]<br />
* [[EF-hand proteins]]<br />
* [[Mesothelioma]]<br />
* [[Ovarian cancer]]<br />
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== References ==<br />
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<references /><br />
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[[Category:Proteins]]<br />
[[Category:Biomarkers]]<br />
[[Category:Cancer diagnosis]]<br />
[[Category:Calcium-binding proteins]]<br />
[[Category:EF-hand proteins]]<br />
[[Category:Mesothelioma]]<br />
[[Category:Ovarian cancer]]<br />
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