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<p><b>New page</b></p><div>[[File:Ideogram_human_chromosome_7.svg|thumb|Ideogram human chromosome 7]] {{Short description|Enzyme in the cytochrome P450 family}}<br />
{{Infobox enzyme<br />
| name = Cytochrome P450 3A5<br />
| image = <br />
| width = <br />
| caption = <br />
| EC_number = 1.14.14.1<br />
| CAS_number = 120831-25-4<br />
| IUBMB_EC_number = 1/14/14/1<br />
| GO_code = 0004503<br />
}}<br />
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'''Cytochrome P450 3A5''' ('''CYP3A5''') is an [[enzyme]] that belongs to the [[cytochrome P450]] family. It is involved in the metabolism of various substances in the body, including [[drugs]], [[steroids]], and [[carcinogens]]. The enzyme is encoded by the '''CYP3A5''' gene, which is located on [[chromosome 7]].<br />
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== Function ==<br />
CYP3A5 is primarily expressed in the [[liver]] and [[intestine]], where it plays a crucial role in the [[oxidation]] of small organic molecules. This enzyme is responsible for the metabolism of approximately 50% of all drugs used in clinical practice, making it a significant player in [[pharmacokinetics]].<br />
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== Genetic Variability ==<br />
The expression of CYP3A5 varies significantly among individuals due to genetic polymorphisms. The most common polymorphism is the CYP3A5*3 allele, which results in a splicing defect and reduced enzyme activity. Individuals with the CYP3A5*1 allele, on the other hand, have higher enzyme activity. This genetic variability can influence drug metabolism and efficacy, leading to personalized medicine approaches.<br />
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== Clinical Significance ==<br />
CYP3A5 is involved in the metabolism of several important drugs, including [[tacrolimus]], [[cyclosporine]], and [[midazolam]]. Variations in CYP3A5 activity can affect drug levels and therapeutic outcomes. For example, individuals with the CYP3A5*1 allele may require higher doses of tacrolimus to achieve therapeutic levels.<br />
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== Related Enzymes ==<br />
CYP3A5 is part of the CYP3A subfamily, which also includes [[CYP3A4]], [[CYP3A7]], and [[CYP3A43]]. These enzymes share similar substrate specificities but differ in their expression patterns and regulatory mechanisms.<br />
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== See Also ==<br />
* [[Cytochrome P450]]<br />
* [[CYP3A4]]<br />
* [[Pharmacogenomics]]<br />
* [[Drug metabolism]]<br />
* [[Liver enzyme]]<br />
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== References ==<br />
{{Reflist}}<br />
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== External Links ==<br />
{{Wikidata|Q148648}}<br />
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[[Category:Cytochrome P450]]<br />
[[Category:Enzymes]]<br />
[[Category:Pharmacogenetics]]<br />
[[Category:Human proteins]]<br />
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