https://wikimd.org/index.php?action=history&feed=atom&title=CY-208%2C243CY-208,243 - Revision history2026-05-01T21:21:26ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.org/index.php?title=CY-208,243&diff=5368408&oldid=prevPrab: CSV import2024-03-06T03:54:10Z<p>CSV import</p>
<p><b>New page</b></p><div>[[File:CY-208,243.png|thumb|{{PAGENAME}}]]<br>'''CY-208,243''' is a [[drug]] that acts as a [[Dopamine receptor|dopamine D1 receptor]] partial [[agonist]], and has [[antipsychotic]] properties. It was researched as a potential treatment for [[schizophrenia]] and [[Parkinson's disease]], but was never marketed.<br />
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==Pharmacology==<br />
'''CY-208,243''' is a [[dopamine]] D1 receptor partial agonist. This means it binds to the D1 receptors in the brain and partially stimulates them, which can have various effects on the body. The D1 receptors are one of the five types of dopamine receptors in the brain, and they are involved in a variety of functions including motor control, cognition, and reward.<br />
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In preclinical studies, CY-208,243 showed antipsychotic-like activity, suggesting it could be useful in the treatment of conditions like schizophrenia. It also showed potential for the treatment of Parkinson's disease, a neurodegenerative disorder characterized by the death of dopamine-producing cells in the brain.<br />
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==History==<br />
'''CY-208,243''' was developed by the pharmaceutical company [[Ciba-Geigy]], now part of [[Novartis]]. It was investigated as a potential treatment for schizophrenia and Parkinson's disease in the 1980s and 1990s, but it was never brought to market. The reasons for this are not publicly known, but could include a variety of factors such as lack of efficacy, undesirable side effects, or commercial considerations.<br />
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==See also==<br />
* [[Dopamine receptor D1]]<br />
* [[Dopamine agonist]]<br />
* [[Antipsychotic]]<br />
* [[Schizophrenia]]<br />
* [[Parkinson's disease]]<br />
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[[Category:Drugs]]<br />
[[Category:Dopamine agonists]]<br />
[[Category:Antipsychotics]]<br />
[[Category:Schizophrenia]]<br />
[[Category:Parkinson's disease]]<br />
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