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	<id>https://wikimd.org/index.php?action=history&amp;feed=atom&amp;title=CXCL2</id>
	<title>CXCL2 - Revision history</title>
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	<updated>2026-05-12T17:19:48Z</updated>
	<subtitle>Revision history for this page on the wiki</subtitle>
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	<entry>
		<id>https://wikimd.org/index.php?title=CXCL2&amp;diff=6499824&amp;oldid=prev</id>
		<title>Prab: CSV import</title>
		<link rel="alternate" type="text/html" href="https://wikimd.org/index.php?title=CXCL2&amp;diff=6499824&amp;oldid=prev"/>
		<updated>2025-03-17T06:02:09Z</updated>

		<summary type="html">&lt;p&gt;CSV import&lt;/p&gt;
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				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;← Older revision&lt;/td&gt;
				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 06:02, 17 March 2025&lt;/td&gt;
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&lt;/table&gt;</summary>
		<author><name>Prab</name></author>
	</entry>
	<entry>
		<id>https://wikimd.org/index.php?title=CXCL2&amp;diff=6216496&amp;oldid=prev</id>
		<title>Prab: CSV import</title>
		<link rel="alternate" type="text/html" href="https://wikimd.org/index.php?title=CXCL2&amp;diff=6216496&amp;oldid=prev"/>
		<updated>2025-02-10T09:23:53Z</updated>

		<summary type="html">&lt;p&gt;CSV import&lt;/p&gt;
&lt;table style=&quot;background-color: #fff; color: #202122;&quot; data-mw=&quot;interface&quot;&gt;
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				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 09:23, 10 February 2025&lt;/td&gt;
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&lt;/table&gt;</summary>
		<author><name>Prab</name></author>
	</entry>
	<entry>
		<id>https://wikimd.org/index.php?title=CXCL2&amp;diff=5298639&amp;oldid=prev</id>
		<title>Prab: CSV import</title>
		<link rel="alternate" type="text/html" href="https://wikimd.org/index.php?title=CXCL2&amp;diff=5298639&amp;oldid=prev"/>
		<updated>2024-02-25T21:31:35Z</updated>

		<summary type="html">&lt;p&gt;CSV import&lt;/p&gt;
&lt;p&gt;&lt;b&gt;New page&lt;/b&gt;&lt;/p&gt;&lt;div&gt;&amp;#039;&amp;#039;&amp;#039;CXCL2&amp;#039;&amp;#039;&amp;#039; is a small [[cytokine]] belonging to the [[CXC chemokine]] family that is also known as macrophage inflammatory protein 2-alpha (MIP2-alpha), GRO2 oncogene (GRO2), and chemokine (C-X-C motif) ligand 2. This chemokine is secreted by [[monocytes]] and [[macrophages]] and is chemotactic for [[polymorphonuclear leukocytes]] and [[hematopoietic stem cells]]. The gene for CXCL2 is located on human chromosome 4 amongst other members of the CXC chemokine family.&lt;br /&gt;
&lt;br /&gt;
== Function ==&lt;br /&gt;
CXCL2 mobilizes cells by interacting with a cell surface chemokine receptor called [[CXCR2]]. It is a powerful [[neutrophil]] chemoattractant and activator, which has roles in immune and inflammatory responses. The CXCL2 protein is produced following stimulation by the inflammatory cytokines [[interleukin-1]] or [[tumor necrosis factor-alpha]]. Expression of CXCL2 can be induced by [[NF-kappaB]], which is a protein complex that controls transcription of DNA.&lt;br /&gt;
&lt;br /&gt;
== Clinical significance ==&lt;br /&gt;
CXCL2 has been implicated in various diseases, including [[rheumatoid arthritis]] and [[cancer]]. In the context of cancer, it can promote [[angiogenesis]], [[tumor growth]], and [[metastasis]]. It is also involved in the inflammation and tissue damage associated with [[myocardial infarction]] (heart attack).&lt;br /&gt;
&lt;br /&gt;
== See also ==&lt;br /&gt;
* [[CXC chemokine]]&lt;br /&gt;
* [[Chemokine]]&lt;br /&gt;
* [[CXCR2]]&lt;br /&gt;
* [[NF-kappaB]]&lt;br /&gt;
&lt;br /&gt;
== References ==&lt;br /&gt;
&amp;lt;references /&amp;gt;&lt;br /&gt;
&lt;br /&gt;
== External links ==&lt;br /&gt;
* [https://www.ncbi.nlm.nih.gov/gene/2921 CXCL2] at the US National Library of Medicine [[Medical Subject Headings]] (MeSH)&lt;br /&gt;
&lt;br /&gt;
[[Category:Cytokines]]&lt;br /&gt;
[[Category:Chemokines]]&lt;br /&gt;
[[Category:Genes on human chromosome 4]]&lt;br /&gt;
&lt;br /&gt;
{{Chemokines}}&lt;br /&gt;
{{Cytokines}}&lt;br /&gt;
{{stub}}&lt;/div&gt;</summary>
		<author><name>Prab</name></author>
	</entry>
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