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	~~'''~~CUMYL-PEGACLONE''' is a [[synthetic cannabinoid]] that is also a new [[psychoactive substance]]. It was first identified in a smoking mixture in Japan in 2016. It is a derivative of [[CUMYL-4CN-BINACA]] but differs in that the 1-amino-3-methyl-1-oxobutanyl group is replaced with a [[PEG]]-based structure.		{{DISPLAYTITLE:CUMYL-PEGACLONE}}

	==~~Chemistry~~==		== Overview ==
	CUMYL-PEGACLONE is a synthetic cannabinoid that is ~~structurally related to~~ the ~~class of drugs as~~ [[~~synthetic cannabinoids~~]] as [[~~AB-CHMINACA~~]]. ~~However, the traditional nitrogen moiety~~ is ~~replaced with~~ a ~~structure~~ known as ~~a PEGylated moiety. This change makes it structurally different from other~~ synthetic cannabinoids ~~and it is the first instance where a PEGylated moiety has~~ been ~~used~~ in ~~the design of a new synthetic cannabinoid~~.		'''CUMYL-PEGACLONE''' is a synthetic cannabinoid that has been used in [[recreational drug]]s. It is a potent agonist of the [[cannabinoid receptor]]s, primarily the [[CB1 receptor]]. CUMYL-PEGACLONE is part of a class of compounds known as [[indazole]]-based synthetic cannabinoids, which have been developed for research purposes but have also been found in [[designer drug]]s.

	==~~Pharmacology~~==		== Chemical Structure ==
	~~The pharmacology~~ of CUMYL-PEGACLONE is ~~largely unknown~~ as ~~there have been no formal studies on its effects~~. ~~However, it is known~~ to ~~be a potent agonist~~ of the ~~[[CB1 receptor]]~~, ~~which is~~ the ~~same receptor that [[THC]], the main active ingredient in [[cannabis]], binds~~ to.		[[File:CUMYL-PEGACLONE.svg\|thumb\|right\|Chemical structure of CUMYL-PEGACLONE]]
			CUMYL-PEGACLONE is chemically classified as an indazole-3-carboxamide. Its structure includes a cumyl group attached to the nitrogen of the indazole ring, and a pentyl chain linked to the carbonyl group. The presence of these groups contributes to its high affinity for cannabinoid receptors.

	==~~Legal Status~~==		== Pharmacology ==
	CUMYL-PEGACLONE is ~~currently a legal grey area in many countries~~. ~~It is not explicitly listed in most national drug laws~~, ~~but its structural similarity to other illegal cannabinoids could potentially make it illegal under analogue laws in some jurisdictions~~.		CUMYL-PEGACLONE acts as a full agonist at the CB1 receptor, which is primarily responsible for the psychoactive effects of cannabinoids. The activation of CB1 receptors by CUMYL-PEGACLONE can lead to effects similar to those of [[tetrahydrocannabinol]] (THC), the active component of [[cannabis]]. These effects may include [[euphoria]], [[altered perception]], and [[cognitive impairment]].

	==~~See Also~~==		== Legal Status ==
			Due to its potential for abuse and lack of medical use, CUMYL-PEGACLONE is controlled in many jurisdictions. It is often included in legislation targeting [[new psychoactive substances]] (NPS) and synthetic cannabinoids. The legal status can vary significantly between countries and regions.

			== Health Risks ==
			The use of CUMYL-PEGACLONE, like other synthetic cannabinoids, can pose significant health risks. Adverse effects may include [[tachycardia]], [[hypertension]], [[anxiety]], [[paranoia]], and in severe cases, [[psychosis]]. The variability in potency and purity of synthetic cannabinoid products increases the risk of overdose and toxic reactions.

			== Related Pages ==
	* [[Synthetic cannabinoids]]		* [[Synthetic cannabinoids]]
	* [[~~CUMYL-4CN-BINACA~~]]		* [[Cannabinoid receptor]]
	* [[~~AB-CHMINACA~~]]		* [[Designer drug]]
	* [[~~Cannabis~~]]		* [[Tetrahydrocannabinol]]

	[[Category:Synthetic cannabinoids]]		[[Category:Synthetic cannabinoids]]
	[[Category:Designer drugs]]		[[Category:Designer drugs]]
	~~[[Category:Cannabinoids]]~~

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'''CUMYL-PEGACLONE''' is a [[synthetic cannabinoid]] that is also a new [[psychoactive substance]]. It was first identified in a smoking mixture in Japan in 2016. It is a derivative of [[CUMYL-4CN-BINACA]] but differs in that the 1-amino-3-methyl-1-oxobutanyl group is replaced with a [[PEG]]-based structure.

==Chemistry==
CUMYL-PEGACLONE is a synthetic cannabinoid that is structurally related to the class of drugs as [[synthetic cannabinoids]] as [[AB-CHMINACA]]. However, the traditional nitrogen moiety is replaced with a structure known as a PEGylated moiety. This change makes it structurally different from other synthetic cannabinoids and it is the first instance where a PEGylated moiety has been used in the design of a new synthetic cannabinoid.

==Pharmacology==
The pharmacology of CUMYL-PEGACLONE is largely unknown as there have been no formal studies on its effects. However, it is known to be a potent agonist of the [[CB1 receptor]], which is the same receptor that [[THC]], the main active ingredient in [[cannabis]], binds to.

==Legal Status==
CUMYL-PEGACLONE is currently a legal grey area in many countries. It is not explicitly listed in most national drug laws, but its structural similarity to other illegal cannabinoids could potentially make it illegal under analogue laws in some jurisdictions.

==See Also==
* [[Synthetic cannabinoids]]
* [[CUMYL-4CN-BINACA]]
* [[AB-CHMINACA]]
* [[Cannabis]]

[[Category:Synthetic cannabinoids]]
[[Category:Designer drugs]]
[[Category:Cannabinoids]]

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CUMYL-PEGACLONE - Revision history

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