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CREB-binding protein - Revision history
2026-04-25T11:39:52Z
Revision history for this page on the wiki
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https://wikimd.org/index.php?title=CREB-binding_protein&diff=6319770&oldid=prev
Prab: CSV import
2025-02-18T04:59:14Z
<p>CSV import</p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 04:59, 18 February 2025</td>
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Prab
https://wikimd.org/index.php?title=CREB-binding_protein&diff=5325566&oldid=prev
Prab: CSV import
2024-02-28T20:43:23Z
<p>CSV import</p>
<p><b>New page</b></p><div>'''CREB-binding protein''' ('''CBP''') is a [[protein]] that in humans is encoded by the ''CREBBP'' [[gene]]. CBP and its closely related family member [[p300 (gene)|p300]] are well known as [[transcriptional coactivator]]s involved in various cellular processes, including [[cell growth]], [[differentiation]], and [[apoptosis]], through the interaction with a variety of [[transcription factor]]s.<br />
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== Function ==<br />
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CBP and p300 have histone acetyltransferase (HAT) activity, which allows them to acetylate [[histone]]s and other proteins. This acetylation can loosen the structure of [[chromatin]], thereby promoting [[gene transcription]]. In addition to their HAT activity, CBP and p300 can also act as a bridge to bring together other proteins needed for the transcription process.<br />
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== Clinical significance ==<br />
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Mutations in the ''CREBBP'' gene are associated with [[Rubinstein-Taybi syndrome]], a rare genetic disorder characterized by mental retardation, growth retardation, and distinctive facial features. In addition, CBP is often targeted by viral proteins and is involved in the pathogenesis of several types of cancer.<br />
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== See also ==<br />
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* [[CREB]]<br />
* [[Transcription (genetics)]]<br />
* [[Histone acetyltransferase]]<br />
* [[Rubinstein-Taybi syndrome]]<br />
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== References ==<br />
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{{Reflist}}<br />
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[[Category:Proteins]]<br />
[[Category:Genes]]<br />
[[Category:Transcription (genetics)]]<br />
[[Category:Cell biology]]<br />
{{protein-stub}}<br />
{{gene-stub}}</div>
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