CPK-MB test - Revision history

Prab: CSV import

2025-02-15T11:00:32Z

CSV import

@@ Line 1: / Line 1: @@
-{{Infobox diagnostic
+== CPK-MB Test ==
-<youtube>
+The '''CPK-MB test''' is a blood test used to measure the level of the MB isoenzyme of [[Creatine kinase]] (CK) in the blood. This test is primarily used to diagnose [[myocardial infarction]] (heart attack) and to assess the extent of heart muscle damage.
-The CPK-MB, often abbreviated as CKMB, is a very [[sensitivity|sensitive]] and [[specificity|specific]] test for the diagnosis of an [[acute myocardial infarction]]
+[[File:AMI_bloodtests_engl.png|thumb|right|Diagram showing blood tests used in diagnosing acute myocardial infarction, including CPK-MB.]]
-==What is CPK?==
+=== Background ===
-==Where is CPK found?==
+[[Creatine kinase]] is an enzyme found in various tissues, including the heart, brain, and skeletal muscle. It plays a crucial role in energy production by catalyzing the conversion of creatine and utilizing adenosine triphosphate (ATP) to create phosphocreatine and adenosine diphosphate (ADP). CK has three isoenzymes: CK-MM, CK-BB, and CK-MB. The CK-MB isoenzyme is predominantly found in cardiac muscle, making it a useful marker for heart muscle damage.
-==What are the types of CPK enzymes?==
+=== Clinical Use ===
-==What does CPK-MB test measure?==
+The CPK-MB test is particularly useful in the context of [[acute coronary syndrome]] (ACS) and suspected [[myocardial infarction]]. When heart muscle is damaged, as in the case of a heart attack, CK-MB is released into the bloodstream. Measuring the levels of CK-MB can help determine the presence and severity of a myocardial infarction.
-==References==
+=== Procedure ===
-[[Category:Blood tests]]
+The test involves drawing a blood sample from a vein, usually in the arm. The blood is then analyzed in a laboratory to measure the concentration of CK-MB. Elevated levels of CK-MB in the blood can indicate heart muscle damage.
 [[Category:Cardiology]]

Prab: CSV import

2025-02-10T09:05:39Z

CSV import

← Older revision		Revision as of 09:05, 10 February 2025
Line 83:		Line 83:
	[[Category:Blood tests]]		[[Category:Blood tests]]
	[[Category:Cardiology]]		[[Category:Cardiology]]
			{{No image}}

Prab at 02:58, 2 May 2022

2022-05-02T02:58:35Z

New page

{{Infobox diagnostic
| Name = CPK-MB test
| Image = AMI bloodtests engl.png
| Alt =
| Caption = Kinetics of cardiac markers in myocardial infarction with or without reperfusion treatment.
| DiseasesDB =
| ICD10 =
| ICD9 =
| ICDO =
| MedlinePlus =
| eMedicine =
| MeshID =
| LOINC = {{LOINC|49551-5}}, {{LOINC|51506-4}}, {{LOINC|2154-3}}, {{LOINC|13969-1}}, {{LOINC|32673-6}}, {{LOINC|38482-6}}
| HCPCSlevel2 =
| Reference_range =
}}
==Definition==

<youtube>
title='''{{PAGENAME}}'''
movie_url=http://www.youtube.com/v/tKqLKeHbNho
&rel=1
embed_source_url=http://www.youtube.com/v/tKqLKeHbNho
&rel=1
wrap = yes
width=750
height=600
</youtube>

The CPK-MB, often abbreviated as CKMB, is a very [[sensitivity|sensitive]] and [[specificity|specific]] test for the diagnosis of an [[acute myocardial infarction]]
==What does the test measure?==
The CPK-MB test measures the amount of creatine kinase (CK) MB fraction in the blood.

==What is CPK?==
CK stands for [[creatine kinase]] or creatine phospokinase (CPK), which is a type of protein that acts as an [[enzyme]].

==Where is CPK found?==
CK is mostly found in your skeletal muscles and heart, with lesser amounts in the brain.

==What are the types of CPK enzymes?==
* CK-MM, found in skeletal muscles
* CK-MB, found in the heart muscle
* CK-BB, found in brain tissue

==What does CPK-MB test measure?==
* The '''CPK-MB test''' is a [[cardiac marker]]<ref name="pmid339548">{{cite journal |author=Guzy PM |title=Creatine phosphokinase-MB (CPK-MB) and the diagnosis of myocardial infarction |journal=West. J. Med. |volume=127 |issue=6 |pages=455–60 |date=December 1977 |pmid=339548 |pmc=1237914 |doi= |url=}}</ref> used to assist diagnoses of an acute [[Acute myocardial infarction|myocardial infarction]].
* It measures the blood level of CK-MB (creatine kinase-muscle/brain), the bound combination of two variants (isoenzymes [[CKM (gene)|CKM]] and [[CKB (gene)|CKB]]) of the enzyme [[phosphocreatine kinase]].
==Is troponin test better?==
* In some locations, the test has been superseded by the [[troponin test]].
* However, recently, there have been improvements to the test that involve measuring the ratio of the CK-MB1 and CK-MB2 isoforms.<ref name="urlUse of Cardiac Markers in the Emergency Department: - eMedicine">{{cite web |url=http://emedicine.medscape.com/article/811905-overview |title=Use of Cardiac Markers in the Emergency Department: - eMedicine |format= |website= |accessdate=2009-01-10}}</ref>
==What are the cardiac related isoforms?==
The newer test detects different [[isoforms]] of the B subunit specific to the myocardium whereas the older test detected the presence of cardiac-related [[isoenzyme]] dimers.
==Variations==
* Many cases of CK-MB levels exceeding the blood level of total CK have been reported, especially in newborns with cardiac malformations, especially ventricular septal defects.
* The reversal of ratios is in favor of pulmonary emboli or vasculitis.
* An autoimmune reaction creating a complex molecule of CK and IgG should be taken into consideration.<ref>{{cite journal |author1=Boucek RJ Jr |author2=Kasselberg AG |author3=Boerth RC |author4=Parrish MD |author5=Graham TP Jr |title=Myocardial injury in infants with congenital heart disease: evaluation by creatine kinase MB isoenzyme analysis |journal=Am J Cardiol |volume=50 |issue=1 |pages=129–35 |date=July 1982 |pmid=7090995 |pmc= |doi= 10.1016/0002-9149(82)90018-2|url=}}</ref>

==References==
{{reflist|2}}
{{faq1}}
* What is CK-MB in MI?
* What is normal CK-MB?
* Why CPK test is done?
* How is CK-MB test done?
* How do you calculate CPK?
* What is a good CPK value?
* Is CK-MB cardiac specific?
* How can I reduce my CK-MB?
* When should CK-MB be tested?
* Can stress increase CK levels?
* What happens if CPK MB is high?
* What are the 3 cardiac enzymes?
* What does MB stand for in CK-MB?
* What causes CK-MB to be elevated?
* How can I lower my CPK naturally?
* How long does CK-MB stay elevated?
* Which rises first troponin or CK-MB?
* Is CK-MB more specific than troponin?
* Why CK-MB is important in myocardial infarction?
{{stb2}}
{{Blood tests}}

[[Category:Blood tests]]
[[Category:Cardiology]]