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← Older revision		Revision as of 21:36, 27 December 2024
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	~~'''COUP-TFI'''~~

	~~[[File:~~COUP-TFI~~.png~~\|~~thumb~~\|~~right~~\|COUP-~~TFI protein structure]]~~		{{Infobox protein
			\| name = COUP-TFI
			\| image = <!-- Image removed -->
			\| caption = <!-- Image caption -->
			\| symbol = NR2F1
			\| alt_symbols = COUP-TF1, EAR-3
			\| EntrezGene = 7025
			\| HGNCid = 7979
			\| OMIM = 600161
			\| RefSeq = NM_005654
			\| UniProt = P10589
			\| PDB = 1H9F
			}}

	'''COUP-TFI''', also known as '''~~Chicken Ovalbumin Upstream Promoter Transcription Factor I~~''', is a ~~member of the [[steroid receptor superfamily]] of~~ [[nuclear receptor]]~~s. It is encoded by the '''NR2F1''' gene in humans. COUP-TFI~~ plays a crucial role in the development and differentiation ~~of various tissues and organs in the body~~.		'''COUP-TFI''' (Chicken Ovalbumin Upstream Promoter-Transcription Factor I), also known as '''NR2F1''', is a [[nuclear receptor]] that plays a crucial role in the regulation of [[gene expression]] during [[development]] and [[cell differentiation]].

	== Function ==		== Function ==
			COUP-TFI is a member of the [[nuclear receptor family]] of intracellular [[transcription factors]]. It is involved in the regulation of several [[biological processes]], including [[neurogenesis]], [[organogenesis]], and [[metabolism]]. COUP-TFI functions by binding to specific [[DNA sequences]] known as [[response elements]], thereby modulating the transcription of target genes.

	COUP-TFI is ~~a transcription factor that binds to direct repeats of~~ the ~~sequence 5'-AGGTCA-3'. It is involved in the regulation of several genes, including those involved in the development~~ of the [[central nervous system]], [[~~retina~~]], [[~~inner ear~~]], and [[~~adrenal gland~~]]. It also ~~plays a role~~ in the ~~regulation~~ of [[~~metabolism~~]] and [[~~circadian rhythm~~]].		== Role in Development ==
			During [[embryonic development]], COUP-TFI is essential for the proper formation of the [[central nervous system]] and the [[peripheral nervous system]]. It regulates the expression of genes involved in [[neuronal differentiation]] and [[axon guidance]]. COUP-TFI is also implicated in the development of the [[cardiovascular system]] and the [[limbs]].

	== Clinical Significance ==		== Clinical Significance ==
			Mutations or dysregulation of COUP-TFI have been associated with various [[developmental disorders]] and [[diseases]]. For instance, alterations in COUP-TFI expression have been linked to [[congenital heart defects]], [[intellectual disability]], and [[autism spectrum disorders]].

	~~Mutations in the NR2F1 gene can lead to~~ [[~~Bosch-Boonstra-Schaaf optic atrophy syndrome~~]]~~, a rare neurological disorder characterized by~~ [[~~optic atrophy~~]], [[~~intellectual disability~~]], [[~~hypotonia~~]], ~~and [[seizures]]~~.		== Interactions ==
			COUP-TFI interacts with other [[transcription factors]] and [[co-regulators]] to exert its effects on gene expression. It can form [[heterodimers]] with other nuclear receptors, such as [[RXR]] (Retinoid X Receptor), to enhance or repress the transcription of target genes.

	== Research ==		== Research ==
			Ongoing research is focused on understanding the precise mechanisms by which COUP-TFI regulates gene expression and its role in [[disease pathogenesis]]. Studies are also exploring the potential of targeting COUP-TFI for therapeutic interventions in diseases where its function is disrupted.
	~~Research~~ on COUP-TFI ~~has been focused on~~ its role in the ~~development~~ of ~~various tissues and organs, as well as its potential involvement~~ in ~~various~~ diseases~~, including [[cancer]], [[neurological disorders]], and [[metabolic disorders]]~~.

	== See Also ==		== See Also ==

	* [[Nuclear receptor]]		* [[Nuclear receptor]]
	* [[Transcription factor]]		* [[Transcription factor]]
	* [[~~Bosch-Boonstra-Schaaf optic atrophy syndrome~~]]		* [[Gene expression]]
			* [[Developmental biology]]

	== References ==		== References ==
			<references/>

	~~<references />~~		== External Links ==
			* [COUP-TFI at the US National Library of Medicine Medical Subject Headings (MeSH)]
			* [NR2F1 gene information at NCBI]

	[[Category:Transcription factors]]		[[Category:Transcription factors]]
	[[Category:Nuclear receptors]]		[[Category:Nuclear receptors]]
			[[Category:Developmental biology]]
	[[Category:Human proteins]]		[[Category:Human proteins]]
	~~[[Category:Genes]]~~
	~~[[Category:Medicine]]~~

	~~{{medicine-stub}}~~

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2024-03-09T21:37:55Z

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'''COUP-TFI'''

[[File:COUP-TFI.png|thumb|right|COUP-TFI protein structure]]

'''COUP-TFI''', also known as '''Chicken Ovalbumin Upstream Promoter Transcription Factor I''', is a member of the [[steroid receptor superfamily]] of [[nuclear receptor]]s. It is encoded by the '''NR2F1''' gene in humans. COUP-TFI plays a crucial role in the development and differentiation of various tissues and organs in the body.

== Function ==

COUP-TFI is a transcription factor that binds to direct repeats of the sequence 5'-AGGTCA-3'. It is involved in the regulation of several genes, including those involved in the development of the [[central nervous system]], [[retina]], [[inner ear]], and [[adrenal gland]]. It also plays a role in the regulation of [[metabolism]] and [[circadian rhythm]].

== Clinical Significance ==

Mutations in the NR2F1 gene can lead to [[Bosch-Boonstra-Schaaf optic atrophy syndrome]], a rare neurological disorder characterized by [[optic atrophy]], [[intellectual disability]], [[hypotonia]], and [[seizures]].

== Research ==

Research on COUP-TFI has been focused on its role in the development of various tissues and organs, as well as its potential involvement in various diseases, including [[cancer]], [[neurological disorders]], and [[metabolic disorders]].

== See Also ==

* [[Nuclear receptor]]
* [[Transcription factor]]
* [[Bosch-Boonstra-Schaaf optic atrophy syndrome]]

== References ==

<references />

[[Category:Transcription factors]]
[[Category:Nuclear receptors]]
[[Category:Human proteins]]
[[Category:Genes]]
[[Category:Medicine]]

{{medicine-stub}}

COUP-TFI - Revision history

Prab: CSV import

Prab: CSV import