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<p><b>New page</b></p><div>'''CD70''' is a [[protein]] that in humans is encoded by the ''CD70'' [[gene]]. CD70 is a member of the [[tumor necrosis factor (TNF)]] ligand family. This cytokine is a ligand for [[TNF receptor]] superfamily member 27 (TNFRSF27/CD27). It is a surface antigen on activated [[B cells]] and activated [[T cells]], and is induced by [[interleukin-2 (IL-2)]].<br />
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== Function ==<br />
CD70 is a [[transmembrane protein]] that is expressed on activated [[lymphocytes]]. It interacts with CD27 to play a crucial role in [[T cell]] activation, [[B cell]] proliferation and differentiation, [[cytotoxic T cell]] induction, and [[immunoglobulin]] synthesis.<br />
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== Clinical significance ==<br />
CD70 has been implicated in various diseases. It is overexpressed in [[renal cell carcinoma]] and is associated with poor prognosis. It is also involved in [[autoimmune diseases]], and blocking CD70-CD27 interactions has been proposed as a therapeutic strategy.<br />
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== Interactions ==<br />
CD70 has been shown to [[Protein-protein interaction|interact]] with [[CD27]].<br />
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== References ==<br />
<references/><br />
* ''et al.'' (1997). "CD70 is critical for CD28-independent CD8+ T cell proliferation". ''J. Immunol.'' '''158''' (8): 3635–3637. PMID 9103409.<br />
* ''et al.'' (1997). "CD70 is selectively expressed on Th1 but not on Th2 cells and is required for Th1-type immune responses". ''J. Immunol.'' '''158''' (9): 4026–4034. PMID 9126981.<br />
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== External links ==<br />
* [https://www.ncbi.nlm.nih.gov/gene/970 CD70] at the US National Library of Medicine [[Medical Subject Headings (MeSH)]]<br />
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[[Category:Clusters of differentiation]]<br />
[[Category:Immunology]]<br />
[[Category:Proteins]]<br />
[[Category:Genes]]<br />
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