Kondreddy Naveen at 00:06, 12 July 2024

2024-07-12T00:06:02Z

← Older revision		Revision as of 00:06, 12 July 2024
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	'''CD200''' is a type of [[protein]] that in humans is encoded by the ''CD200'' [[gene]]. It is also known as OX-2 membrane glycoprotein. CD200 is a member of the [[immunoglobulin superfamily]] and is involved in the regulation of [[immune response]]s.		'''CD200''' is a type of [[protein]] that in humans is encoded by the ''CD200'' [[gene]]. It is also known as OX-2 membrane glycoprotein. CD200 is a member of the [[immunoglobulin superfamily]] and is involved in the regulation of [[immune response]]s.

			[[File:CD200.png\|thumb\|right\|300px\|Structure of the CD200 protein.]]

	== Structure ==		== Structure ==
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	Research is ongoing to develop therapeutic strategies that target CD200 and its receptor. These strategies could potentially be used to treat a variety of conditions, from autoimmune diseases to cancer.		Research is ongoing to develop therapeutic strategies that target CD200 and its receptor. These strategies could potentially be used to treat a variety of conditions, from autoimmune diseases to cancer.

	~~[[File:CD200 protein structure.jpg\|thumb\|right\|300px\|Structure of the CD200 protein.]]~~

	== See also ==		== See also ==

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'''CD200''' is a type of [[protein]] that in humans is encoded by the ''CD200'' [[gene]]. It is also known as OX-2 membrane glycoprotein. CD200 is a member of the [[immunoglobulin superfamily]] and is involved in the regulation of [[immune response]]s.

== Structure ==
CD200 is a type 1 membrane glycoprotein, which contains two [[immunoglobulin domains]]. The extracellular domain of CD200 is responsible for its immunoregulatory function. It interacts with the CD200 receptor (CD200R) on the surface of certain immune cells.

== Function ==
CD200 has been shown to play a role in the regulation of [[macrophage]] activation and function. It does this by interacting with its receptor, CD200R, which is primarily expressed on the surface of myeloid lineage cells. This interaction leads to the suppression of [[T cell]] responses and provides a mechanism for the control of inflammatory responses.

In addition to its role in controlling immune responses, CD200 has also been implicated in [[neuroprotection]]. It is expressed in various tissues including neurons, endothelial cells, and in certain tumors.

== Clinical significance ==
Alterations in the expression of CD200 have been associated with a variety of diseases. For example, increased expression of CD200 has been observed in certain types of [[cancer]], including [[melanoma]], [[ovarian cancer]], and certain types of [[leukemia]]. This overexpression may contribute to the immune evasion of these tumors.

Conversely, decreased expression of CD200 has been associated with autoimmune diseases such as [[multiple sclerosis]] and [[rheumatoid arthritis]]. In these conditions, the lack of CD200 expression may contribute to the overactive immune response seen in these diseases.

== Research ==
Research is ongoing to develop therapeutic strategies that target CD200 and its receptor. These strategies could potentially be used to treat a variety of conditions, from autoimmune diseases to cancer.

[[File:CD200 protein structure.jpg|thumb|right|300px|Structure of the CD200 protein.]]

== See also ==
* [[Cluster of differentiation]]
* [[Immunoglobulin superfamily]]
* [[Immune response]]
* [[Macrophage]]
* [[T cell]]
* [[Cancer]]
* [[Autoimmune disease]]

== References ==
<references />

{{Proteins}}
{{Immunology-stub}}
[[Category:Proteins]]
[[Category:Immunology]]
[[Category:Genes]]
[[Category:Medicine]]

CD200 - Revision history

Kondreddy Naveen at 00:06, 12 July 2024

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