https://wikimd.org/index.php?action=history&feed=atom&title=CD19 CD19 - Revision history 2026-05-08T22:05:11Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.org/index.php?title=CD19&diff=6527579&oldid=prev Prab at 17:15, 18 March 2025 2025-03-18T17:15:06Z <p></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 17:15, 18 March 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l25">Line 25:</td> <td colspan="2" class="diff-lineno">Line 25:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; 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font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">__NOINDEX__</del></div></td><td colspan="2" class="diff-side-added"></td></tr> </table> Prab https://wikimd.org/index.php?title=CD19&diff=6499325&oldid=prev Prab: CSV import 2025-03-17T05:34:08Z <p>CSV import</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 05:34, 17 March 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l25">Line 25:</td> <td colspan="2" class="diff-lineno">Line 25:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; 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color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{medicine-stub}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{medicine-stub}}</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">{{No image}}</ins></div></td></tr> </table> Prab https://wikimd.org/index.php?title=CD19&diff=5382620&oldid=prev Prab: CSV import 2024-03-10T20:09:26Z <p>CSV import</p> <p><b>New page</b></p><div>&#039;&#039;&#039;CD19&#039;&#039;&#039; is a type of [[protein]] that in humans is encoded by the &#039;&#039;CD19&#039;&#039; [[gene]]. It is a member of the immunoglobulin superfamily and has two [[immunoglobulin (Ig)]] domains. The CD19 protein is expressed on the surface of [[B cells]], a type of [[white blood cell]].<br /> <br /> == Structure ==<br /> The CD19 protein is a 95 kDa transmembrane glycoprotein that consists of 556 amino acids. It has a large extracellular domain that contains two Ig domains, and a small cytoplasmic domain that contains multiple phosphorylation sites.<br /> <br /> == Function ==<br /> CD19 plays a crucial role in establishing intrinsic B cell signaling thresholds through modulating both B cell receptor (BCR)-dependent and independent signaling. It works in conjunction with CD21, CD81, and CD225 in the B cell co-receptor complex. The extracellular domain of CD19 interacts with the B cell receptor, while the cytoplasmic domain interacts with signaling molecules such as [[phosphatidylinositol 3-kinase]] (PI3K) and [[Lyn kinase]].<br /> <br /> == Clinical significance ==<br /> Alterations in CD19 expression levels or mutations in its gene have been implicated in various diseases. For instance, CD19 is often overexpressed in [[B cell lymphoma]] and [[leukemia]], and is a target for various immunotherapies including [[CAR-T cell therapy]]. In contrast, CD19 deficiency is associated with hypogammaglobulinemia, a condition characterized by low levels of immunoglobulins and increased susceptibility to infections.<br /> <br /> == See also ==<br /> * [[Cluster of differentiation]]<br /> * [[B cell receptor]]<br /> * [[Immunoglobulin superfamily]]<br /> <br /> == References ==<br /> &lt;references /&gt;<br /> <br /> [[Category:Clusters of differentiation]]<br /> [[Category:Immunology]]<br /> [[Category:Proteins]]<br /> [[Category:Genes]]<br /> <br /> {{medicine-stub}}</div> Prab