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	'''~~CD151‏‎''' (also known as '''Cluster of Differentiation 151~~''') is a [[protein]] that in humans is encoded by the ~~CD151‏‎ [[~~gene]]. It is a member of the [[~~transmembrane 4 superfamily~~]], also known as the [[~~tetraspanin~~]] ~~family~~. ~~These proteins mediate signal transduction events~~ that ~~play a role in~~ the ~~regulation~~ of ~~cell development~~, ~~activation~~, ~~growth~~ and ~~motility~~.		== CD151 ==

			[[File:Fibrosarcoma_cells_CD151.jpg\|thumb\|right\|Fibrosarcoma cells expressing CD151]]

			'''CD151''' is a protein that in humans is encoded by the ''CD151'' gene. It is a member of the [[tetraspanin]] family, which are cell surface proteins involved in the regulation of cell development, activation, growth, and motility. CD151 is also known as the [[Cluster of differentiation\|cluster of differentiation]] 151.

			== Structure ==

			CD151 is a transmembrane protein that spans the cell membrane four times, characteristic of the tetraspanin family. It has two extracellular loops, a small intracellular loop, and short cytoplasmic tails. The large extracellular loop is involved in protein-protein interactions, which are crucial for its function in cell adhesion and signaling.

	== Function ==		== Function ==

	~~CD151‏‎ forms complexes with other tetraspanin proteins~~, ~~integrins~~, and ~~other proteins and acts as a molecular organizer of a variety of membrane proteins~~. It is ~~involved in~~ the ~~regulation~~ of cell ~~adhesion~~ and ~~motility~~. ~~This protein is also involved~~ in ~~the growth of certain types of~~ [[tumor]]s.		CD151 plays a significant role in cell adhesion, migration, and signaling. It is known to associate with [[integrins]], particularly [[integrin alpha3]] and [[integrin alpha6]], forming complexes that are important for the stabilization of cell-cell and cell-matrix interactions. These interactions are critical in processes such as [[angiogenesis]], [[tumor metastasis]], and [[wound healing]].

	== Clinical ~~significance~~ ==		== Clinical Significance ==

	~~Mutations~~ in ~~the CD151‏‎ gene are~~ associated with ~~the rare genetic condition~~ [[~~Epidermolysis bullosa~~]], ~~which causes the skin to become very fragile~~ and to ~~blister easily~~. In addition, ~~CD151‏‎ has been implicated~~ in the ~~progression of certain types of cancer, including~~ [[~~breast cancer~~]] and [[~~prostate cancer~~]].		CD151 has been implicated in various pathological conditions, including cancer. It is often overexpressed in [[carcinomas]] and is associated with poor prognosis in several types of cancer, such as [[breast cancer]], [[prostate cancer]], and [[melanoma]]. CD151 promotes cancer cell migration and invasion, contributing to [[metastasis]].

			In addition to its role in cancer, CD151 is involved in [[kidney disease]]. Mutations in the ''CD151'' gene can lead to [[nephropathy]] and [[hearing loss]], as seen in some genetic syndromes.

	== Research ==		== Research ==

	Research ~~into the function~~ and potential therapeutic ~~uses of CD151‏‎ is ongoing~~. ~~It is thought that understanding more about this protein could lead~~ to ~~new treatments for a variety of conditions, including skin disorders~~ and ~~cancer~~.		Research on CD151 is ongoing to better understand its role in disease and its potential as a therapeutic target. Inhibiting CD151 function has been proposed as a strategy to prevent cancer metastasis. Studies are also exploring its role in [[angiogenesis]] and its potential impact on [[cardiovascular disease]].

	== ~~See also~~ ==		== Related pages ==

	* [[Cluster of differentiation]]
	* [[Tetraspanin]]		* [[Tetraspanin]]
	* [[~~Epidermolysis bullosa~~]]		* [[Integrin]]
	* [[~~Breast cancer~~]]		* [[Cell adhesion]]
	* [[~~Prostate cancer~~]]		* [[Cancer metastasis]]

	~~== References ==~~

	~~{{reflist}}~~

	~~[[Category:Proteins]]~~		[[Category:Cell surface proteins]]
	~~[[Category:Genes]]~~		[[Category:Clusters of differentiation]]
	[[Category:Cell ~~biology~~]]		[[Category:Human proteins]]
	[[Category:~~Oncology~~]]
	[[Category:~~Dermatology~~]]
	~~{{protein-stub}}~~
	~~{{gene-stub}}~~
	~~{{medicine-stub}}~~

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2024-02-28T22:13:05Z

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'''CD151‏‎''' (also known as '''Cluster of Differentiation 151''') is a [[protein]] that in humans is encoded by the CD151‏‎ [[gene]]. It is a member of the [[transmembrane 4 superfamily]], also known as the [[tetraspanin]] family. These proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.

== Function ==

CD151‏‎ forms complexes with other tetraspanin proteins, integrins, and other proteins and acts as a molecular organizer of a variety of membrane proteins. It is involved in the regulation of cell adhesion and motility. This protein is also involved in the growth of certain types of [[tumor]]s.

== Clinical significance ==

Mutations in the CD151‏‎ gene are associated with the rare genetic condition [[Epidermolysis bullosa]], which causes the skin to become very fragile and to blister easily. In addition, CD151‏‎ has been implicated in the progression of certain types of cancer, including [[breast cancer]] and [[prostate cancer]].

== Research ==

Research into the function and potential therapeutic uses of CD151‏‎ is ongoing. It is thought that understanding more about this protein could lead to new treatments for a variety of conditions, including skin disorders and cancer.

== See also ==

* [[Cluster of differentiation]]
* [[Tetraspanin]]
* [[Epidermolysis bullosa]]
* [[Breast cancer]]
* [[Prostate cancer]]

== References ==

{{reflist}}

[[Category:Proteins]]
[[Category:Genes]]
[[Category:Cell biology]]
[[Category:Oncology]]
[[Category:Dermatology]]
{{protein-stub}}
{{gene-stub}}
{{medicine-stub}}

CD151 - Revision history

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