https://wikimd.com/index.php?action=history&feed=atom&title=CD109 2026-04-24T18:14:58Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.com/index.php?title=CD109&diff=6499576&oldid=prev 2025-03-17T05:51:55Z

<p>CSV import</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 05:51, 17 March 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l30">Line 30:</td> <td colspan="2" class="diff-lineno">Line 30:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Oncology]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Oncology]]</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{No image}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{No image}}</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">__NOINDEX__</ins></div></td></tr> </table>

Prab https://wikimd.com/index.php?title=CD109&diff=6215591&oldid=prev 2025-02-10T08:53:15Z

<p>CSV import</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 08:53, 10 February 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l29">Line 29:</td> <td colspan="2" class="diff-lineno">Line 29:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Immunology]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Immunology]]</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Oncology]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Oncology]]</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">{{No image}}</ins></div></td></tr> </table>

Prab https://wikimd.com/index.php?title=CD109&diff=6019171&oldid=prev 2024-11-28T18:59:54Z

<p>CSV import</p> <p><b>New page</b></p><div>{{DISPLAYTITLE:CD109}}<br /> <br /> &#039;&#039;&#039;CD109&#039;&#039;&#039; is a glycosylphosphatidylinositol (GPI)-anchored glycoprotein that is a member of the α2-macroglobulin/C3, C4, C5 family of thioester-containing proteins. It is expressed on the surface of various cell types, including [[platelets]], activated [[T-cells]], and certain [[cancer]] cells. CD109 is involved in the regulation of [[transforming growth factor beta]] (TGF-β) signaling, which plays a crucial role in cell proliferation, differentiation, and immune responses.<br /> <br /> ==Structure and Function==<br /> CD109 is a large glycoprotein with a molecular weight of approximately 170 kDa. It is anchored to the cell membrane via a GPI anchor, which allows it to be released from the cell surface by phospholipase enzymes. The protein contains several domains, including a thioester bond that is characteristic of the α2-macroglobulin family.<br /> <br /> CD109 modulates TGF-β signaling by binding to TGF-β receptors and inhibiting their activity. This interaction can lead to the downregulation of TGF-β-mediated cellular responses, which is important in controlling cell growth and immune function. Dysregulation of CD109 expression or function has been implicated in various pathological conditions, including [[cancer]] and [[fibrosis]].<br /> <br /> ==Expression and Clinical Significance==<br /> CD109 is expressed in a variety of tissues, with high levels found in the [[skin]], [[lung]], and [[liver]]. It is also present on the surface of [[platelets]] and activated [[T-cells]]. In the context of cancer, CD109 expression has been observed in [[squamous cell carcinoma]], [[melanoma]], and other tumor types. Its role in cancer is complex, as it can both promote and inhibit tumor progression depending on the context.<br /> <br /> In addition to its role in cancer, CD109 has been studied in the context of [[autoimmune diseases]] and [[fibrotic disorders]]. Its ability to modulate TGF-β signaling makes it a potential therapeutic target for conditions characterized by excessive fibrosis or immune dysregulation.<br /> <br /> ==Research and Therapeutic Potential==<br /> Research on CD109 is ongoing, with studies focusing on its role in cancer biology, immune regulation, and tissue repair. The development of CD109-targeted therapies is an area of interest, particularly for diseases where TGF-β signaling is dysregulated. Potential therapeutic strategies include the use of antibodies or small molecules to modulate CD109 activity or expression.<br /> <br /> ==Also see==<br /> * [[Transforming growth factor beta]]<br /> * [[Glycosylphosphatidylinositol]]<br /> * [[Thioester-containing proteins]]<br /> * [[Cancer biology]]<br /> * [[Immune regulation]]<br /> <br /> {{Reflist}}<br /> {{Medical-stub}}<br /> <br /> [[Category:Cell surface antigens]]<br /> [[Category:Immunology]]<br /> [[Category:Oncology]]</div>

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