https://wikimd.com/index.php?action=history&feed=atom&title=ButofilololButofilolol - Revision history2026-04-23T01:29:38ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.com/index.php?title=Butofilolol&diff=5804132&oldid=prevPrab: CSV import2024-05-20T06:08:22Z<p>CSV import</p>
<p><b>New page</b></p><div>[[File:Butofilolol_skeletal.svg|thumb|right]] '''Butofilolol''' is a [[beta-adrenergic antagonist]] (beta-blocker) used in the treatment of [[hypertension]] and other cardiovascular conditions. It is a non-selective beta-blocker, meaning it blocks both [[beta-1 adrenergic receptor|beta-1]] and [[beta-2 adrenergic receptor|beta-2]] adrenergic receptors.<br />
<br />
==Pharmacology==<br />
Butofilolol works by inhibiting the action of [[epinephrine]] and [[norepinephrine]] on beta-adrenergic receptors, which are part of the [[sympathetic nervous system]]. This leads to a decrease in [[heart rate]], [[cardiac output]], and [[blood pressure]]. By reducing the workload on the heart, butofilolol helps to manage conditions such as [[angina pectoris]] and [[myocardial infarction]].<br />
<br />
==Indications==<br />
Butofilolol is primarily indicated for:<br />
* [[Hypertension]]<br />
* [[Angina pectoris]]<br />
* [[Arrhythmia]]<br />
* [[Myocardial infarction]]<br />
<br />
==Side Effects==<br />
Common side effects of butofilolol include:<br />
* [[Bradycardia]]<br />
* [[Hypotension]]<br />
* [[Fatigue]]<br />
* [[Dizziness]]<br />
* [[Cold extremities]]<br />
<br />
Less common but more serious side effects may include:<br />
* [[Bronchospasm]]<br />
* [[Heart failure]]<br />
* [[Depression]]<br />
<br />
==Contraindications==<br />
Butofilolol should not be used in patients with:<br />
* [[Asthma]] or other severe [[chronic obstructive pulmonary disease|COPD]]<br />
* [[Severe bradycardia]]<br />
* [[Cardiogenic shock]]<br />
* [[Second or third-degree heart block]] without a pacemaker<br />
<br />
==Mechanism of Action==<br />
Butofilolol blocks the beta-adrenergic receptors in the heart and blood vessels. This action reduces the effects of [[sympathetic nervous system]] stimulation, leading to a decrease in heart rate and blood pressure. The reduction in cardiac output and peripheral resistance helps to lower blood pressure and reduce the oxygen demand of the heart.<br />
<br />
==Dosage and Administration==<br />
The dosage of butofilolol varies depending on the condition being treated and the patient's response to the medication. It is typically administered orally, and the dosage may be adjusted based on the patient's blood pressure and heart rate.<br />
<br />
==See Also==<br />
* [[Beta blocker]]<br />
* [[Hypertension]]<br />
* [[Cardiovascular disease]]<br />
* [[Adrenergic receptor]]<br />
<br />
==References==<br />
{{Reflist}}<br />
<br />
[[Category:Beta blockers]]<br />
[[Category:Antihypertensive agents]]<br />
[[Category:Cardiovascular drugs]]<br />
[[Category:Medicine]]<br />
<br />
{{medicine-stub}}</div>Prab