Bromazepam - Revision history

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2025-03-23T10:48:34Z

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← Older revision		Revision as of 10:48, 23 March 2025
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	'''Bromazepam''' is a [[benzodiazepine]] ~~derivative drug, patented by Roche in 1963 and developed clinically in~~ the ~~1970s. It possesses~~ [[~~anxiolytic]], [[sedative]], [[hypnotic]], [[anticonvulsant]], [[muscle relaxant~~]] and [[~~amnesic~~]] ~~properties~~. ~~Bromazepam~~ is ~~most commonly used as a short-term treatment~~ for [[anxiety disorders]] and ~~panic attacks~~.		{{Short description\|Benzodiazepine medication}}
			{{Drugbox
			\| verifiedfields = changed
			\| verifiedrevid = 477002648
			\| image = Bromazepam.svg
			\| image2 = Bromazepam-from-xtal-3D-balls.png
			\| image2_caption = 3D model of Bromazepam
			}}

			'''Bromazepam''' is a [[benzodiazepine]] medication primarily used for the treatment of [[anxiety]] and [[insomnia]]. It is known for its calming effects and is often prescribed to alleviate symptoms of anxiety disorders. Bromazepam is marketed under various brand names, including Lexotan and Lexotanil.

	==Pharmacology==		==Pharmacology==
	Bromazepam ~~binds to~~ the [[GABA_A receptor]], ~~causing a conformational change~~ and ~~increasing inhibitory effects of [[GABA]]~~. ~~Further, bromazepam may inhibit voltage dependent sodium channels~~ to ~~a lesser extent. The half-life of bromazepam is 12-20 hours~~.		Bromazepam works by enhancing the effect of the neurotransmitter [[gamma-aminobutyric acid]] (GABA) at the [[GABA_A receptor]], which results in sedative, anxiolytic, muscle relaxant, and anticonvulsant properties. This action helps to calm the nervous system and reduce anxiety.

	==Medical uses==		==Medical uses==
	Bromazepam is ~~indicated~~ for the short-term treatment of [[insomnia]], short-term ~~treatment of anxiety or panic attacks, if a [[benzodiazepine]] is required, and the alleviation of the symptoms of alcohol- and drug-withdrawal~~.		Bromazepam is primarily prescribed for the short-term relief of severe anxiety, which can be disabling or subjecting the individual to extreme distress. It is also used in the treatment of [[insomnia]] associated with anxiety. Due to its potential for dependence, it is generally recommended for short-term use.

	==Side effects==		==Side effects==
	Common side effects of bromazepam ~~are similar to those of other benzodiazepines and can~~ include drowsiness, fatigue, ~~light-headedness~~, and ~~dry mouth~~. ~~Less common side effects~~ can ~~include~~ [[~~dysphoria~~]], ~~changes~~ in ~~libido~~, ~~and muscle weakness~~.		Common side effects of bromazepam include drowsiness, dizziness, and fatigue. In some cases, it may cause confusion, ataxia, and impaired coordination. Long-term use can lead to [[tolerance]] and [[dependence]], and abrupt discontinuation may result in withdrawal symptoms.

			==Synthesis==
			[[File:Bromazepam_synthesis.png\|Bromazepam synthesis\|thumb\|right]]
			Bromazepam is synthesized through a series of chemical reactions starting from 2-amino-5-bromobenzophenone. The synthesis involves the formation of a diazepine ring, which is characteristic of benzodiazepines.

			==Brand names==
			Bromazepam is marketed under several brand names, including:
			* '''Lexotan'''
			* '''Lexotanil'''

	~~==Interactions==~~		[[File:Lexotan.jpg\|Lexotan packaging\|thumb\|left]]
	~~Bromazepam can interact with a number of medications, including other~~ [[~~CNS depressants~~]]~~, certain~~ [[~~antidepressants]~~]~~, and certain [[antibiotics~~]~~]. It is important to consult with a healthcare provider before starting or stopping any medications.~~		[[File:Lexotanil_6_mg.png\|Lexotanil 6 mg tablets\|thumb\|right]]

	==~~See also~~==		==Legal status==
			Bromazepam is classified as a controlled substance in many countries due to its potential for abuse and dependence. Its legal status varies, and it is available by prescription only in most regions.

			==Related pages==
	* [[Benzodiazepine]]		* [[Benzodiazepine]]
	* [[GABA_A receptor]]
	* [[Anxiety disorder]]		* [[Anxiety disorder]]
	* [[Insomnia]]		* [[Insomnia]]
			* [[Gamma-aminobutyric acid]]

			[[Category:Benzodiazepines]]
	[[Category:Anxiolytics]]		[[Category:Anxiolytics]]
	[[Category:~~Benzodiazepines~~]]		[[Category:Sedatives]]
	~~[[Category:Hypnotics]]~~
	~~[[Category:Roche brands]]~~

	~~{{medicine-stub}}~~
	~~== Bromazepam ==~~
	~~<gallery>~~
	~~File:Lexotan.jpg\|Lexotan~~
	~~File:Lexotanil_6_mg.png\|Lexotanil 6 mg~~
	~~File:Bromazepam_synthesis.png\|Bromazepam synthesis~~
	~~</gallery>~~
	~~<gallery>~~
	~~File:Bromazepam.svg\|Bromazepam chemical structure~~
	~~File:Bromazepam-from-xtal-3D-balls.png\|3D model of Bromazepam~~
	~~File:Lexotan.jpg\|Lexotan packaging~~
	~~File:Lexotanil_6_mg.png\|Lexotanil 6 mg tablets~~
	~~File:Bromazepam_synthesis.png\|Bromazepam synthesis~~
	~~</gallery>~~

Prab: CSV import

2025-02-18T05:00:27Z

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← Older revision		Revision as of 05:00, 18 February 2025
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	File:Lexotan.jpg\|Lexotan		File:Lexotan.jpg\|Lexotan
	File:Lexotanil_6_mg.png\|Lexotanil 6 mg		File:Lexotanil_6_mg.png\|Lexotanil 6 mg
			File:Bromazepam_synthesis.png\|Bromazepam synthesis
			</gallery>
			<gallery>
			File:Bromazepam.svg\|Bromazepam chemical structure
			File:Bromazepam-from-xtal-3D-balls.png\|3D model of Bromazepam
			File:Lexotan.jpg\|Lexotan packaging
			File:Lexotanil_6_mg.png\|Lexotanil 6 mg tablets
	File:Bromazepam_synthesis.png\|Bromazepam synthesis		File:Bromazepam_synthesis.png\|Bromazepam synthesis
	</gallery>		</gallery>

Prab: CSV import

2025-02-18T01:57:18Z

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← Older revision		Revision as of 01:57, 18 February 2025
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	{{medicine-stub}}		{{medicine-stub}}
			== Bromazepam ==
			<gallery>
			File:Lexotan.jpg\|Lexotan
			File:Lexotanil_6_mg.png\|Lexotanil 6 mg
			File:Bromazepam_synthesis.png\|Bromazepam synthesis
			</gallery>

Prab: CSV import

2024-03-10T20:23:28Z

CSV import

New page

'''Bromazepam''' is a [[benzodiazepine]] derivative drug, patented by Roche in 1963 and developed clinically in the 1970s. It possesses [[anxiolytic]], [[sedative]], [[hypnotic]], [[anticonvulsant]], [[muscle relaxant]] and [[amnesic]] properties. Bromazepam is most commonly used as a short-term treatment for [[anxiety disorders]] and panic attacks.

==Pharmacology==
Bromazepam binds to the [[GABA_A receptor]], causing a conformational change and increasing inhibitory effects of [[GABA]]. Further, bromazepam may inhibit voltage dependent sodium channels to a lesser extent. The half-life of bromazepam is 12-20 hours.

==Medical uses==
Bromazepam is indicated for the short-term treatment of [[insomnia]], short-term treatment of anxiety or panic attacks, if a [[benzodiazepine]] is required, and the alleviation of the symptoms of alcohol- and drug-withdrawal.

==Side effects==
Common side effects of bromazepam are similar to those of other benzodiazepines and can include drowsiness, fatigue, light-headedness, and dry mouth. Less common side effects can include [[dysphoria]], changes in libido, and muscle weakness.

==Interactions==
Bromazepam can interact with a number of medications, including other [[CNS depressants]], certain [[antidepressants]], and certain [[antibiotics]]. It is important to consult with a healthcare provider before starting or stopping any medications.

==See also==
* [[Benzodiazepine]]
* [[GABA_A receptor]]
* [[Anxiety disorder]]
* [[Insomnia]]

[[Category:Anxiolytics]]
[[Category:Benzodiazepines]]
[[Category:Hypnotics]]
[[Category:Roche brands]]

{{medicine-stub}}

← Older revision		Revision as of 05:00, 18 February 2025
Line 29:		Line 29:
	File:Lexotan.jpg\|Lexotan		File:Lexotan.jpg\|Lexotan
	File:Lexotanil_6_mg.png\|Lexotanil 6 mg		File:Lexotanil_6_mg.png\|Lexotanil 6 mg
			File:Bromazepam_synthesis.png\|Bromazepam synthesis
			</gallery>
			<gallery>
			File:Bromazepam.svg\|Bromazepam chemical structure
			File:Bromazepam-from-xtal-3D-balls.png\|3D model of Bromazepam
			File:Lexotan.jpg\|Lexotan packaging
			File:Lexotanil_6_mg.png\|Lexotanil 6 mg tablets
	File:Bromazepam_synthesis.png\|Bromazepam synthesis		File:Bromazepam_synthesis.png\|Bromazepam synthesis
	</gallery>		</gallery>