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	~~'''~~Bone ~~marrow~~-derived macrophages''' (BMDMs) are a type of [[immune cell]] that originate from [[bone marrow]] stem cells. They are part of the [[mononuclear phagocyte system]], which includes other types of [[macrophages]] and [[dendritic cells]]. BMDMs play a crucial role in the body's immune response, helping to fight off infections and diseases.		== Bone Marrow-Derived Macrophage ==

	~~== Function ==~~		[[File:BMDM_production.png\|thumb\|right\|Diagram of BMDM production]]

	BMDMs ~~function as part~~ of ~~the body's~~ [[~~immune system~~]]~~, helping to protect the body~~ from ~~harmful pathogens. They do this by engulfing and destroying foreign substances, such as bacteria and viruses,~~ in ~~a process known as~~ [[~~phagocytosis~~]]. ~~In addition to their~~ role in immune ~~defense~~, BMDMs ~~also play a role~~ in ~~tissue repair~~ and ~~inflammation~~.		Bone marrow-derived macrophages (BMDMs) are a type of [[macrophage]] that are generated from [[hematopoietic stem cells]] in the [[bone marrow]]. These cells play a crucial role in the [[immune system]], acting as [[phagocytes]] that engulf and digest cellular debris, foreign substances, and pathogens. BMDMs are widely used in research to study macrophage biology and the immune response.

	== Development ==		== Development ==

	BMDMs ~~develop~~ from [[hematopoietic stem cells]] in the bone marrow. ~~These stem~~ cells ~~differentiate into~~ [[~~monocytes~~]], ~~which then leave~~ the ~~bone marrow~~ and ~~enter the bloodstream~~. ~~Once~~ in the ~~tissues, these monocytes can further differentiate into macrophages~~.		BMDMs are derived from [[monocytes]], which are a type of [[white blood cell]] that circulates in the [[bloodstream]]. Monocytes originate from [[hematopoietic stem cells]] in the bone marrow and differentiate into macrophages when they migrate into tissues. The process of differentiation involves several stages, including the development of [[progenitor cells]] and [[precursor cells]] before becoming mature macrophages.

			== Function ==

			Macrophages, including BMDMs, are essential components of the [[innate immune system]]. They are involved in the detection, phagocytosis, and destruction of bacteria and other harmful organisms. Macrophages also play a role in [[antigen presentation]], where they process and present antigens to [[T cells]], thus linking the innate and [[adaptive immune system\|adaptive immune responses]].

			== Research Applications ==

	~~== Role~~ in ~~Disease ==~~		BMDMs are commonly used in laboratory research to study various aspects of macrophage function, including their role in [[inflammation]], [[tissue repair]], and [[immune response]]. They are also used to investigate the effects of different [[cytokines]] and [[growth factors]] on macrophage behavior. The ability to culture BMDMs in vitro provides a valuable tool for studying the molecular mechanisms underlying macrophage activity.

	BMDMs have been implicated in a number of diseases, including [[cancer]], [[autoimmune diseases]], and [[infectious diseases]]. In cancer, BMDMs can promote tumor growth and metastasis. In autoimmune diseases, they can contribute to inflammation and tissue damage. In infectious diseases, they can either help to fight off the infection or, in some cases, be exploited by the pathogen to promote its own survival.		== Related Pages ==

	~~== Research ==~~		* [[Macrophage]]
			* [[Hematopoietic stem cell]]
			* [[Immune system]]
			* [[Phagocytosis]]
			* [[Antigen presentation]]

	Research into BMDMs is ongoing, with scientists seeking to better understand their role in health and disease. This research could potentially lead to new treatments for a variety of conditions, from cancer to autoimmune diseases.		{{Immunology}}

	[[Category:Immunology]]		[[Category:Immunology]]
	[[Category:Cell biology]]		[[Category:Cell biology]]
	~~{{Immunology-stub}}~~
	~~{{Cellbiology-stub}}~~

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2024-03-05T17:13:42Z

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'''Bone marrow-derived macrophages''' (BMDMs) are a type of [[immune cell]] that originate from [[bone marrow]] stem cells. They are part of the [[mononuclear phagocyte system]], which includes other types of [[macrophages]] and [[dendritic cells]]. BMDMs play a crucial role in the body's immune response, helping to fight off infections and diseases.

== Function ==

BMDMs function as part of the body's [[immune system]], helping to protect the body from harmful pathogens. They do this by engulfing and destroying foreign substances, such as bacteria and viruses, in a process known as [[phagocytosis]]. In addition to their role in immune defense, BMDMs also play a role in tissue repair and inflammation.

== Development ==

BMDMs develop from [[hematopoietic stem cells]] in the bone marrow. These stem cells differentiate into [[monocytes]], which then leave the bone marrow and enter the bloodstream. Once in the tissues, these monocytes can further differentiate into macrophages.

== Role in Disease ==

BMDMs have been implicated in a number of diseases, including [[cancer]], [[autoimmune diseases]], and [[infectious diseases]]. In cancer, BMDMs can promote tumor growth and metastasis. In autoimmune diseases, they can contribute to inflammation and tissue damage. In infectious diseases, they can either help to fight off the infection or, in some cases, be exploited by the pathogen to promote its own survival.

== Research ==

Research into BMDMs is ongoing, with scientists seeking to better understand their role in health and disease. This research could potentially lead to new treatments for a variety of conditions, from cancer to autoimmune diseases.

[[Category:Immunology]]
[[Category:Cell biology]]
{{Immunology-stub}}
{{Cellbiology-stub}}

Bone marrow-derived macrophage - Revision history

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