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<p><b>New page</b></p><div>'''Binaltorphimine''' (also known as '''BNI''') is a potent and selective antagonist for the [[kappa opioid receptor]]. It was originally derived from the opioid alkaloid [[nor-binaltorphimine]]. Binaltorphimine has been shown to produce antidepressant-like effects in animal studies.<br />
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==Chemistry==<br />
Binaltorphimine is a derivative of the opioid alkaloid nor-binaltorphimine. It is a potent and selective antagonist for the kappa opioid receptor, with a high affinity for this receptor subtype. The chemical structure of binaltorphimine is characterized by a bis-quaternary structure, which is believed to contribute to its high potency and selectivity.<br />
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==Pharmacology==<br />
Binaltorphimine acts as an antagonist at the kappa opioid receptor, meaning it blocks the action of kappa opioid agonists. It has a high affinity for the kappa opioid receptor, and a much lower affinity for the mu and delta opioid receptors. This selectivity makes binaltorphimine a useful tool in the study of the kappa opioid system.<br />
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==Clinical significance==<br />
The kappa opioid system has been implicated in a number of physiological and pathological processes, including pain, mood disorders, and addiction. Binaltorphimine, as a kappa opioid antagonist, has potential therapeutic applications in these areas. In animal studies, binaltorphimine has been shown to produce antidepressant-like effects, suggesting a potential role in the treatment of depression.<br />
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==See also==<br />
* [[Kappa opioid receptor]]<br />
* [[Opioid antagonist]]<br />
* [[Nor-binaltorphimine]]<br />
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==References==<br />
<references /><br />
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[[Category:Opioids]]<br />
[[Category:Antagonists]]<br />
[[Category:Pharmacology]]<br />
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