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<p>CSV import</p> <p><b>New page</b></p><div>[[File:Benfluorex.svg|thumb|right]] &#039;&#039;&#039;Benfluorex&#039;&#039;&#039; is a [[pharmaceutical drug]] that was primarily used as an [[antidiabetic]] and [[anorectic]] agent. It is chemically related to the [[fenfluramine]] family of drugs. Benfluorex was marketed under various brand names, including [[Mediator]].<br /> <br /> ==Pharmacology==<br /> Benfluorex is a [[serotonin-norepinephrine-dopamine reuptake inhibitor]] (SNDRI) and a [[serotonin releasing agent]] (SRA). It was used to improve [[glycemic control]] in patients with [[type 2 diabetes mellitus]] and to aid in [[weight loss]].<br /> <br /> ==Medical Uses==<br /> Benfluorex was prescribed to patients with [[type 2 diabetes]] to help control blood sugar levels. It was also used as an [[anorectic]] to assist in weight reduction in obese patients.<br /> <br /> ==Adverse Effects==<br /> The use of benfluorex has been associated with serious adverse effects, including [[cardiac valvulopathy]] and [[pulmonary hypertension]]. These risks led to the withdrawal of the drug from the market in several countries.<br /> <br /> ==Regulatory Status==<br /> Benfluorex was withdrawn from the market in [[France]] in 2009 due to its association with severe [[cardiovascular]] side effects. The [[European Medicines Agency]] (EMA) recommended the suspension of marketing authorizations for benfluorex-containing medicines across the [[European Union]] in 2010.<br /> <br /> ==Controversy==<br /> The withdrawal of benfluorex was surrounded by controversy, particularly in France, where it was marketed as Mediator. The drug was linked to numerous cases of [[heart valve disease]] and [[pulmonary hypertension]], leading to significant public outcry and legal actions against the manufacturer.<br /> <br /> ==See Also==<br /> * [[Fenfluramine]]<br /> * [[Type 2 diabetes mellitus]]<br /> * [[Cardiac valvulopathy]]<br /> * [[Pulmonary hypertension]]<br /> <br /> ==References==<br /> {{Reflist}}<br /> <br /> ==External Links==<br /> {{No external links}}<br /> <br /> [[Category:Withdrawn drugs]]<br /> [[Category:Antidiabetic drugs]]<br /> [[Category:Anorectics]]<br /> [[Category:Serotonin-norepinephrine-dopamine reuptake inhibitors]]<br /> [[Category:Serotonin releasing agents]]<br /> [[Category:Cardiovascular toxicology]]<br /> <br /> {{medicine-stub}}</div>

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