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Basmisanil - Revision history
2026-04-24T19:32:11Z
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<p><b>New page</b></p><div>'''Basmisanil''' (also known as '''RG-1662''' and '''RO5186582''') is an experimental drug candidate for the treatment of cognitive impairment associated with Down syndrome. It is being developed by [[Roche (company)|Roche]] and is currently in Phase II clinical trials.<br />
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== Mechanism of Action ==<br />
Basmisanil is a negative allosteric modulator of the [[alpha-5 subunit]] of the [[GABA-A receptor]]. It is hypothesized to work by reducing the excessive inhibition in the brains of individuals with Down syndrome, thereby improving cognitive function.<br />
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== Clinical Trials ==<br />
Basmisanil has undergone Phase I and II clinical trials. The Phase II trial, conducted by Roche, aimed to assess the safety, tolerability, and efficacy of the drug in individuals with Down syndrome aged between 12 and 30 years. However, the results of the trial, published in 2020, showed that Basmisanil did not meet its primary endpoint of improving cognitive function.<br />
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== Future Development ==<br />
Despite the disappointing results of the Phase II trial, research into the potential benefits of Basmisanil continues. Roche has stated that they remain committed to exploring new treatment options for individuals with Down syndrome.<br />
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== See Also ==<br />
* [[Down Syndrome]]<br />
* [[GABA-A receptor]]<br />
* [[Roche (company)]]<br />
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== References ==<br />
<references /><br />
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[[Category:Experimental drugs]]<br />
[[Category:GABA modulators]]<br />
[[Category:Roche products]]<br />
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